ArticleCell proliferation2021
Sterol metabolism and protein metabolism are differentially correlated with sarcopenia in Asian Chinese men and women.
Article in Cell proliferation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Risk prediction models for sarcopenia in maintenance hemodialysis patients: a systematic review and meta-analysis.BMC nephrology · 2025Pooled it
- Start with muscle mass or muscle strength in diagnosis and management of sarcopenia? A systematic review of guidance documents.Asia Pacific journal of clinical nutrition · 2024Pooled it
- Myosteatosis mediates the link between specific dietary components and colorectal carcinogenesis: from PPLSS multi-center study.Asia Pacific journal of clinical nutrition · 2026Article
- Baseline cardio-kidney-metabolic syndrome, its transition, and frailty: insights from the China Health and Retirement Longitudinal Study (CHARLS).European journal of medical research · 2026Article
- Chronic inflammation as a driving factor for sarcopenia: an update on pathophysiology and future therapeutic targets.Frontiers in pharmacology · 2026Review
- Development and validation of nomogram and machine learning models to predict sarcopenia in patients with chronic kidney disease.Scientific reports · 2025Article
- Associations of serum bile acids and amino acids with low skeletal muscle mass among Chinese population: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Exercise as a Metabolic Regulator: Targeting AMPK/mTOR-Autophagy Crosstalk to Counteract Sarcopenic Obesity.Aging and disease · 2025Review
- Genetically Engineered Hypoimmune Human Muscle Progenitor Cells Can Reduce Immune Rejection.Cell proliferation · 2025Article
- The application of Chinese version of SARC-F and SARC-CalF in sarcopenia screening against five definitions: a diagnostic test accuracy study.BMC geriatrics · 2024Article
- Comparative analysis of SARC-F-EBM, Ishii test, and six other screening tools for sarcopenia in Chinese community-dwelling older adults: a cross-sectional diagnostic study.Scientific reports · 2024Article
- The metabaging cycle promotes non-metabolic chronic diseases of ageing.Cell proliferation · 2024Article
- Validity of the modified versions of SARC-F+EBM for sarcopenia screening and diagnosis in China: the PPLSS study.Asia Pacific journal of clinical nutrition · 2024Article
- Muscle Injuries Induce a Prostacyclin-PPARγ/PGC1a-FAO Spike That Boosts Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Spatial metabolomics reveals skeletal myofiber subtypes.Science advances · 2023Article
- Article
- Machine learning-based phenotypic screening for postmitotic growth inducers uncover vitamin D3 metabolites as small molecule ribosome agonists.Cell proliferation · 2022Article
- The Metabaging Cycle.Cell proliferation · 2022Article
- Beneficial effects of whey protein peptides on muscle loss in aging mice models.Frontiers in nutrition · 2022Article
- Sterol metabolism and protein metabolism are differentially correlated with sarcopenia in Asian Chinese men and women.Cell proliferation · 2021Article
Corrections and comments
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Authors and funding
25 authors at 6 institutions in 1 country.
Funding
Abstract
objectivesOur aim was to investigate the prevalence and predictive variables of sarcopenia.
methodsWe recruited participants from the Peking Union Medical College Hospital Multicenter Prospective Longitudinal Sarcopenia Study (PPLSS). Muscle mass was quantified using bioimpedance, and muscle function was quantified using grip strength and gait speed. Logistic regression revealed the relationships between sarcopenia and nutritional, lifestyle, disease, psychosocial and physical variables.
resultsThe prevalence of sarcopenia and sarcopenic obesity was 9.2%-16.2% and 0.26%-9.1%, respectively. Old age, single status, undernourishment, higher income, smoking, low physical activity, poor appetite and low protein diets were significantly associated with sarcopenia. Multiple logistic regression analysis showed that age was a risk factor for all stages of sarcopenia, and participants above 80 years were greater than fivefold more susceptible to sarcopenia, while lower physical activity was an independent risk factor. The optimal cut-off value for age was 71 years, which departs from the commonly accepted cut-off of 60 years. Female participants were greater than twofold less susceptible to sarcopenia than male participants. The sterol derivative 25-hydroxyvitamin D was associated with fourfold lower odds of sarcopenia in male participants. Several protein intake variables were also correlated with sarcopenia. Based on these parameters, we defined a highly predictive index for sarcopenia.
conclusionsOur findings support a predictive index of sarcopenia, which agglomerates the complex influences that sterol metabolism and nutrition exert on male vs female participants.
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