Evidence map›Paper›PMID 33609010›Full record

ArticleJournal of cellular and molecular medicine2021

Novel chimeric TLR2/NOD2 agonist CL429 exhibited significant radioprotective effects in mice.

Ying Cheng, Jicong Du, Ruling Liu, Suhe Dong, Jianming Cai, Fu Gao, Cong Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ying ChengDepartment of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai, China.
Jicong DuDepartment of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai, China.ORCID 0000-0002-2088-4603
Ruling LiuDepartment of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai, China.
Suhe DongDepartment of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai, China.
Jianming CaiDepartment of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai, China.
Fu GaoDepartment of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai, China.
Cong LiuDepartment of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai, China.

Funding

National Natural Science Foundation of China 31800705National Natural Science Foundation of China 81872559National Natural Science Foundation of China 81903260Shanghai Sailing Program 19YF1459100
6 · The paper itself

Abstract

Severe ionizing radiation causes the acute lethal damage of haematopoietic system and gastrointestinal tract. Here, we found CL429, the novel chimeric TLR2/NOD2 agonist, exhibited significant radioprotective effects in mice. CL429 increased mice survival, protected mice against the lethal damage of haematopoietic system and gastrointestinal tract. CL429 was more effective than equivalent amounts of monospecific (TLR2 or NOD2) and combination (TLR2 + NOD2) of molecules in preventing radiation-induced death. The radioprotection of CL429 was mainly mediated by activating TLR2 and partially activating NOD2. CL429-induced radioprotection was largely dependent on the activation of TLR2-MyD88-NF-κB signalling pathway. In conclusion, the data suggested that the co-activation of TLR2 and NOD2 could induce significant synergistic radioprotective effects and CL429 might be a potential high-efficiency selective agent.

Indexed as

Acetylmuramyl-Alanyl-IsoglutamineAcute Radiation SyndromeAnimalsHematopoietic SystemIntestinesMaleMiceMice, Inbred C57BLNod2 Signaling Adaptor ProteinRadiation-Protective AgentsToll-Like Receptor 2Whole-Body IrradiationAcetylmuramyl-Alanyl-IsoglutamineNod2 protein, mouseNod2 Signaling Adaptor ProteinRadiation-Protective AgentsTLR2-NOD2 agonist CL429Tlr2 protein, mouseToll-Like Receptor 2Cl429NOD2radiationradioprotectionTLR2

Identifiers

PMID33609010
PMCPMC8051721
OpenAlexW3130501746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.