Evidence map›Paper›PMID 33608839›Full record

SynthesisWorld journal of pediatrics : WJP2021

Multisystem inflammatory syndrome in pediatric COVID-19 patients: a meta-analysis.

Eman A Toraih, Mohammad H Hussein, Rami M Elshazli, Adam Kline, Ruhul Munshi, Nasrin Sultana, Sharven Taghavi, Mary Killackey, Juan Duchesne, Manal S Fawzy and 1 more

Open access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of pediatrics : WJP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  6. Treatment of multisystem inflammatory syndrome in children.World journal of pediatrics : WJP · 2024
    Review
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  8. Article
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  10. Observational
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
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  18. IVIG plus Glucocorticoids versus IVIG Alone in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: A Systematic Review and Meta-Analysis.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Eman A ToraihDepartment of Surgery, Tulane University, School of Medicine, New Orleans, LA, USA. etoraih@tulane.edu.ORCID http://orcid.org/0000-0001-9267-3787
Mohammad H HusseinDepartment of Surgery, Tulane University, School of Medicine, New Orleans, LA, USA.
Rami M ElshazliDepartment of Biochemistry and Molecular Genetics, Faculty of Physical Therapy, Horus University-Egypt, New Damietta, 34517, Egypt.
Adam KlineTulane University, School of Medicine, New Orleans, LA, USA.
Ruhul MunshiDivision of Endocrine and Oncologic Surgery, Department of Surgery, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.
Nasrin SultanaDepartment of Medicine, Larkin Community Hospital, Florida, Miami, USA.
Sharven TaghaviDepartment of Surgery, Tulane University, School of Medicine, New Orleans, LA, USA.
Mary KillackeyDepartment of Surgery, Tulane University, School of Medicine, New Orleans, LA, USA.
Juan DuchesneTrauma/Acute Care and Critical Care, Department of Surgery, Tulane University, School of Medicine, New Orleans, LA, USA.
Manal S FawzyDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Emad KandilDivision of Endocrine and Oncologic Surgery, Department of Surgery, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.
Tulane University · USSuez Canal University · EGDamietta University · EGLarkin Community Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to systematically review the clinical and laboratory features of patients with the multisystem inflammatory syndrome in pediatrics diagnosed during the COVID-19 pandemic. DATA SOURCES: A literature search in Web of Science, PubMed, Scopus, and Science Direct was made up to June 29, 2020.

resultsAnalysis of 15 articles (318 COVID-19 patients) revealed that although many patients presented with the typical multisystem inflammatory syndrome in pediatrics, Kawasaki-like features as fever (82.4%), polymorphous maculopapular exanthema (63.7%), oral mucosal changes (58.1%), conjunctival injections (56.0%), edematous extremities (40.7%), and cervical lymphadenopathy (28.5%), atypical gastrointestinal (79.4%) and neurocognitive symptoms (31.8%) were also common. They had elevated serum lactic acid dehydrogenase, D-dimer, C-reactive protein, procalcitonin, interleukin-6, troponin I levels, and lymphopenia. Nearly 77.0% developed hypotension, and 68.1% went into shock, while 41.1% had acute kidney injury. Intensive care was needed in 73.7% of cases; 13.2% were intubated, and 37.9% required mechanical ventilation. Intravenous immunoglobulins and steroids were given in 87.7% and 56.9% of the patients, respectively, and anticoagulants were utilized in 67.0%. Pediatric patients were discharged after a hospital stay of 6.77 days on average (95% CI 4.93-8.6).

conclusionsRecognizing the typical and atypical presentation of the multisystem inflammatory syndrome in pediatric COVID-19 patients has important implications in identifying children at risk. Monitoring cardiac and renal decompensation and early interventions in patients with multisystem inflammatory syndrome is critical to prevent further morbidity.

Indexed as

BiomarkersChildCOVID-19Critical CareDiagnosis, DifferentialHumansPandemicsSARS-CoV-2Systemic Inflammatory Response SyndromeBiomarkersCOVID-19Kawasaki-like syndromeMultisystem inflammatory syndrome in pediatricsSARS-CoV-2

Identifiers

PMID33608839
PMCPMC7895741
OpenAlexW3129937345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.