ArticleAmino acids2021
Age-related decline in the taurine content of the skin in rodents.
Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Longitudinal Evidence of Sustained Taurine Deficiency in Inflammatory Bowel Disease.International journal of molecular sciences · 2026Article
- Protective effect of taurine on skin aging caused by deficiency of B cell-specific Moloney MLV insertion site-1.American journal of translational research · 2026Article
- Reduced Taurine Transporter Expression in Lymphoblastoid Cell Lines From Alzheimer's Disease Patients Compared With Age-Matched Controls: Therapeutic Implications?Drug development research · 2025Article
- Investigation of the anti-skin aging effects of taurine through mendelian randomization analysis of its relationship with immune cells.Journal of cosmetic dermatology · 2024Article
- Taurine and Polyphenol Complex Repaired Epidermal Keratinocyte Wounds by Regulating IL8 and TIMP2 Expression.Current issues in molecular biology · 2024Article
- Functions and Metabolism of Amino Acids in the Hair and Skin of Dogs and Cats.Advances in experimental medicine and biology · 2024Article
- Subcellular one carbon metabolism in cancer, aging and epigenetics.Frontiers in epigenetics and epigenomics · 2024Article
- Taurine accelerates the synthesis of ceramides and hyaluronic acid in cultured epidermis and dermal fibroblasts.Experimental and therapeutic medicine · 2023Article
- Taurine deficiency as a driver of aging.Science (New York, N.Y.) · 2023Article
- The Disease-Modifying Role of Taurine and Its Therapeutic Potential in Coronavirus Disease 2019 (COVID-19).Advances in experimental medicine and biology · 2022Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taurine, a sulfur-containing amino acid, occurs at high concentrations in the skin, and plays a role in maintaining the homeostasis of the skin. We investigated the effects of aging on the content and localization of taurine in the skin of mice and rats. Taurine was extracted from the skin samples of hairless mice and Sprague Dawley rats, and the taurine content of the skin was determined by high-performance liquid chromatography (HPLC). The results of the investigation revealed that the taurine content in both the dermis and epidermis of hairless mice declined significantly with age. Similar age-related decline in the skin taurine content was also observed in rats. In contrast, the taurine content in the sole remained unchanged with age. An immunohistochemical analysis also revealed a decreased skin taurine content in aged animals compared with younger animals, although no significant differences in the localization of taurine were observed between the two age groups. Supplementation of the drinking water of aged mice with 3% (w/v) taurine for 4 weeks increased the taurine content of the epidermis, but not the dermis. The present study showed for the first time that the taurine content of the skin decreased with age in mice and rats, which may be related to the impairment of the skin homeostasis observed with aging. The decreased taurine content of the epidermis in aged animals was able to be rescued by taurine supplementation.
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