ArticleCommunications biology2021
Quercetin 3,5,7,3',4'-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1.
Open access · goldAbstract readComparative Study
In one paragraph
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Trial
- SIRT1 in Senescence: Mitochondria and Immune Crosstalk.Biology · 2026Review
- All the Way: A Decade of SIRT1 in Breast Cancer.Biomedicines · 2026Review
- Emerging Role of Sirtuins-Mediated Ferroptosis in Hepatocellular Carcinoma Progression: Mechanisms and Therapeutic Perspectives.Journal of hepatocellular carcinoma · 2026Review
- Sirtuins as Therapeutic Targets for Treating Cancer, Metabolic Diseases, and Neurodegenerative Diseases.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Formulation Strategies for Immunomodulatory Natural Products in 3D Tumor Spheroids and Organoids: Current Challenges and Emerging Solutions.Pharmaceutics · 2025Review
- Integrating untargeted volatile metabolomics and molecular evidence supporting chemotaxonomy in Kaempferia species for more effective identification.Scientific reports · 2025Article
- Effects of quercetin and derivatives on NAMPT/Sirtuin-1 metabolic pathway in neuronal cells: an approach to mitigate chemotherapy-induced cognitive impairment.Metabolic brain disease · 2025Article
- Anticancer Activity and Molecular Mechanisms of Acetylated and Methylated Quercetin in Human Breast Cancer Cells.Molecules (Basel, Switzerland) · 2024Article
- Quercetin and Related Analogs as Therapeutics to Promote Tissue Repair.Bioengineering (Basel, Switzerland) · 2023Review
- The industrially important genusFrontiers in pharmacology · 2023Review
- New insights into Sirt1: potential therapeutic targets for the treatment of cerebral ischemic stroke.Frontiers in cellular neuroscience · 2023Review
- The differing effects of a dual acting regulator on SIRT1.Frontiers in molecular biosciences · 2023Article
- Quercetin Decreases Corneal Haze In Vivo and Influences Gene Expression of TGF-Beta Mediators In Vitro.Metabolites · 2022Article
- Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration.Antioxidants (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 3 institutions in 1 country.
Mimin ZhangDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0003-3089-5477
Peng LuDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-1405-5294
Tohru TeradaDepartment of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-7091-0646
Miaomiao SuiDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-2644-9215
Haruka FurutaDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Kilico IidaDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Yukie KatayamaDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Yi LuDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-2540-6598
Ken OkamotoDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0003-2760-5344
Michio SuzukiDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0001-6150-8957
Tomiko AsakuraDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0003-2097-7284
Kentaro ShimizuDepartment of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-3245-0052
Fumihiko HakunoDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-4447-6225
Shin-Ichiro TakahashiDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-2323-2010
Norimoto ShimadaTokiwa Phytochemical Co. Ltd., Sakura, Chiba, Japan.ORCID http://orcid.org/0000-0002-6049-989X
Jinwei YangTokiwa Phytochemical Co. Ltd., Sakura, Chiba, Japan.ORCID http://orcid.org/0000-0002-3045-5052
Tsutomu IshikawaTokiwa Phytochemical Co. Ltd., Sakura, Chiba, Japan.ORCID http://orcid.org/0000-0003-4516-153X
Jin TatsuzakiTokiwa Phytochemical Co. Ltd., Sakura, Chiba, Japan.ORCID http://orcid.org/0000-0001-6161-5787
Koji NagataDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. aknagata@mail.ecc.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-4704-0603
The University of Tokyo · JPKyoritsu Women's University · JPTokyo University of Agriculture · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sirtuin 1 (SIRT1), an NAD
Indexed as
ZingiberaceaeAllosteric RegulationAntineoplastic Agents, PhytogenicBinding SitesBreast NeoplasmsEnzyme ActivationEnzyme ActivatorsFemaleHumansMCF-7 CellsMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingProtein Conformation, alpha-HelicalQuercetinResveratrolAntineoplastic Agents, PhytogenicEnzyme ActivatorsQuercetinResveratrolSIRT1 protein, humanSirtuin 1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.