Evidence map›Paper›PMID 33608611›Full record

ArticleCommunications biology2021

Engineering multifunctional bactericidal nanofibers for abdominal hernia repair.

Samson Afewerki, Nicole Bassous, Samarah Vargas Harb, Marcus Alexandre F Corat, Sushila Maharjan, Guillermo U Ruiz-Esparza, Mirian M M de Paula, Thomas J Webster, Carla Roberta Tim, Bartolomeu Cruz Viana and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Samson AfewerkiDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. samsonafewerki20@gmail.com.ORCID 0000-0002-5108-6487
Nicole BassousNanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, USA.
Samarah Vargas HarbNanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, USA.ORCID 0000-0001-7148-4661
Marcus Alexandre F CoratMultidisciplinary Center for Biological Research, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.ORCID 0000-0002-8801-2318
Sushila MaharjanDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Guillermo U Ruiz-EsparzaDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mirian M M de PaulaMultidisciplinary Center for Biological Research, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Thomas J WebsterNanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, USA.
Carla Roberta TimBrasil University, Itaquera, São Paulo, Brazil.
Bartolomeu Cruz VianaLIMAV - Interdisciplinary Laboratory for Advanced Materials, Materials Science & Engineering Graduate Program, UFPI - Federal University of Piaui, Teresina, Piaui, Brazil.
Danquan WangNanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, USA.
Xichi WangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Fernanda Roberta MarcianoNanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, USA.ORCID 0000-0001-7740-8766
Anderson Oliveira LoboDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. lobo@ufpi.edu.br.ORCID 0000-0002-2544-0438

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The engineering of multifunctional surgical bactericidal nanofibers with inherent suitable mechanical and biological properties, through facile and cheap fabrication technology, is a great challenge. Moreover, hernia, which is when organ is pushed through an opening in the muscle or adjacent tissue due to damage of tissue structure or function, is a dire clinical challenge that currently needs surgery for recovery. Nevertheless, post-surgical hernia complications, like infection, fibrosis, tissue adhesions, scaffold rejection, inflammation, and recurrence still remain important clinical problems. Herein, through an integrated electrospinning, plasma treatment and direct surface modification strategy, multifunctional bactericidal nanofibers were engineered showing optimal properties for hernia repair. The nanofibers displayed good bactericidal activity, low inflammatory response, good biodegradation, as well as optimal collagen-, stress fiber- and blood vessel formation and associated tissue ingrowth in vivo. The disclosed engineering strategy serves as a prominent platform for the design of other multifunctional materials for various biomedical challenges.

Indexed as

Biocompatible MaterialsNanofibersTissue ScaffoldsAnimalsAnti-Bacterial AgentsDisease Models, AnimalGelatinHernia, AbdominalHerniorrhaphyMethacrylatesMiceNanomedicineNIH 3T3 CellsPolyestersRatsSurgical Wound InfectionAnti-Bacterial AgentsBiocompatible MaterialsGelatingelatin methacryloylMethacrylatespolycaprolactonePolyesters

Identifiers

PMID33608611
PMCPMC7896057

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.