Evidence map›Paper›PMID 33608505›Full record

ArticleCell death & disease2021

Deletion of FGF9 in GABAergic neurons causes epilepsy.

Moran Guo, Can Cui, Xueqin Song, Lijing Jia, Duan Li, Xiuli Wang, Hui Dong, Yanqin Ma, Yaling Liu, Zhiqiang Cui and 7 more

Open access · goldAbstract readVideo-Audio Media
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. FGF family in health and disease.Molecular biomedicine · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Moran Guo *Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.ORCID 0000-0001-6308-2929
Can Cui *Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
Xueqin Song *Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
Lijing JiaDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
Duan LiDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
Xiuli WangDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
Hui DongDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
Yanqin MaJiangsu Nhwa Pharm. Co. Ltd, Nantong, Jiangsu, 210000, China.
Yaling LiuDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
Zhiqiang CuiHebei General Hospital, Shijiazhuang, Hebei, 050000, China.
Le YiDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
Zhongyao LiDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
Yue BiDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
Yuanyuan LiDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
Yakun LiuDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
Weisong DuanDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China. duanweisong0912@sina.com.
Chunyan LiDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China. hebeichunyanli@aliyun.com.ORCID 0000-0002-7963-1803
Hebei Medical University · CNHebei General Hospital · CNJiangsu Nhwa Pharmaceutical (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibroblast growth factor 9 (FGF9) has long been assumed to modulate multiple biological processes, yet very little is known about the impact of FGF9 on neurodevelopment. Herein, we found that loss of Fgf9 in olig1 progenitor cells induced epilepsy in mice, with pathological changes in the cortex. Then depleting Fgf9 in different neural populations revealed that epilepsy was associated with GABAergic neurons. Fgf9 CKO in GABAergic neuron (CKO

Indexed as

Adenylyl CyclasesAdultAnimalsAnticonvulsantsApoptosisCase-Control StudiesCerebral CortexCyclic AMPDisease Models, AnimalEpilepsyExtracellular Signal-Regulated MAP KinasesFemaleFibroblast Growth Factor 9GABAergic NeuronsGenetic Predisposition to DiseaseHumansAdenylyl CyclasesAnticonvulsantsCyclic AMPExtracellular Signal-Regulated MAP KinasesFGF9 protein, humanFgf9 protein, mouseFibroblast Growth Factor 9Recombinant Proteins

Identifiers

PMID33608505
PMCPMC7896082
OpenAlexW3132110697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.