Evidence map›Paper›PMID 33608381›Full record

ArticleCold Spring Harbor molecular case studies2021

Treatment-emergent neuroendocrine prostate cancer with a germline

Deep Pandya, Myra Shah, Fuat Kaplan, Candice Martino, Gillian Levy, Mia Kazanjian, Stephen Batter, John Martignetti, Richard C Frank

Open access · diamondAbstract read
In one paragraph

Article in Cold Spring Harbor molecular case studies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  12. Case reports in oncology
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Deep Pandya *Rudy L. Ruggles Biomedical Research Institute, Nuvance Health, Danbury, Connecticut 06810, USA.
Myra Shah *Department of Medicine, Norwalk Hospital, Nuvance Health, Norwalk, Connecticut 06856, USA.
Fuat KaplanRudy L. Ruggles Biomedical Research Institute, Nuvance Health, Danbury, Connecticut 06810, USA.
Candice MartinoRudy L. Ruggles Biomedical Research Institute, Nuvance Health, Danbury, Connecticut 06810, USA.
Gillian LevyDepartment of Pathology, Norwalk Hospital, Nuvance Health, Norwalk, Connecticut 06856, USA.
Mia KazanjianDepartment of Radiology, Norwalk Hospital, Nuvance Health, Norwalk, Connecticut 06856, USA.
Stephen BatterDepartment of Urology, Norwalk Hospital, Nuvance Health, Norwalk, Connecticut 06856, USA.
John MartignettiRudy L. Ruggles Biomedical Research Institute, Nuvance Health, Danbury, Connecticut 06810, USA.
Richard C FrankRudy L. Ruggles Biomedical Research Institute, Nuvance Health, Danbury, Connecticut 06810, USA.
Biomedical Research Institute · USNorwalk Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroendocrine prostate cancer (NEPC) is a highly aggressive histologic subtype of prostate cancer associated with a poor prognosis. Its incidence is expected to increase as castration-resistant disease emerges from the widespread use of potent androgen receptor-targeting therapies, such as abiraterone and enzalutamide. Defects in homologous recombination repair genes, such as

Indexed as

Germ CellsMutationAgedAndrostenesAntineoplastic AgentsBRCA1 ProteinBRCA2 ProteinDrug Resistance, NeoplasmDrug TherapyGenes, BRCA1Genes, BRCA2HumansMalePhthalazinesPiperazinesPlatinumabirateroneAndrostenesAntineoplastic AgentsBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanolaparibPhthalazinesPiperazinesPlatinumPoly(ADP-ribose) Polymerase Inhibitorsprostate cancer

Identifiers

PMID33608381
PMCPMC7903888
OpenAlexW3133123607

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.