ArticleScience advances2021
The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters.
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
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41 citing papers in PubMed, 53 citations in OpenAlex.
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Corrections and comments
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Authors and funding
21 authors at 5 institutions in 3 countries.
Florian A RosenbergerMax Planck Institute Biology of Ageing-Karolinska Institutet Laboratory, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0003-4604-6170
David MooreMax Planck Institute Biology of Ageing-Karolinska Institutet Laboratory, Karolinska Institutet, 171 65 Stockholm, Sweden.
Ilian AtanassovProteomics Core Facility, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.ORCID 0000-0001-8259-2545
Marco F MoedasMax Planck Institute Biology of Ageing-Karolinska Institutet Laboratory, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0001-5461-0320
Paula ClementeMax Planck Institute Biology of Ageing-Karolinska Institutet Laboratory, Karolinska Institutet, 171 65 Stockholm, Sweden.
Ákos VégváriDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0002-1287-0906
Najla El FissiMax Planck Institute Biology of Ageing-Karolinska Institutet Laboratory, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0002-6631-4630
Roberta FilogranaMax Planck Institute Biology of Ageing-Karolinska Institutet Laboratory, Karolinska Institutet, 171 65 Stockholm, Sweden.
Anna-Lena BucherDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0002-9391-4850
Yvonne HinzeProteomics Core Facility, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.ORCID 0000-0002-2966-9862
Matthew TheScience for Life Laboratory, KTH-Royal Institute of Technology, 171 65 Stockholm, Sweden.ORCID 0000-0002-5401-5553
Erik HedmanCentre for Inherited Metabolic Diseases, Karolinska University Hospital, 171 76 Stockholm, Sweden.ORCID 0000-0003-4017-9749
Ekaterina ChernogubovaCardiovascular Medicine Unit, Department of Medicine (Solna), Karolinska Institutet, 171 65 Stockholm, Sweden.
Arjana BegzatiDepartment of Pharmacology, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-8770-8022
Rolf WibomCentre for Inherited Metabolic Diseases, Karolinska University Hospital, 171 76 Stockholm, Sweden.ORCID 0000-0001-6721-4642
Mohit JainDepartment of Pharmacology, University of California San Diego, La Jolla, CA, USA.
Roland NilssonCardiovascular Medicine Unit, Department of Medicine (Solna), Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0002-6020-7498
Lukas KällScience for Life Laboratory, KTH-Royal Institute of Technology, 171 65 Stockholm, Sweden.ORCID 0000-0001-5689-9797
Anna WedellMax Planck Institute Biology of Ageing-Karolinska Institutet Laboratory, Karolinska Institutet, 171 65 Stockholm, Sweden.
Christoph FreyerMax Planck Institute Biology of Ageing-Karolinska Institutet Laboratory, Karolinska Institutet, 171 65 Stockholm, Sweden. anna.wredenberg@ki.se christoph.freyer@ki.se.ORCID 0000-0003-0418-1673
Anna WredenbergMax Planck Institute Biology of Ageing-Karolinska Institutet Laboratory, Karolinska Institutet, 171 65 Stockholm, Sweden. anna.wredenberg@ki.se christoph.freyer@ki.se.ORCID 0000-0002-2500-6121
Karolinska Institutet · SEKarolinska University Hospital · SEKTH Royal Institute of Technology · SEMax Planck Institute for Biology of Ageing · DEUniversity of California San Diego · US
Funding
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5MNIH HHS P40 OD018537
Abstract
Induction of the one-carbon cycle is an early hallmark of mitochondrial dysfunction and cancer metabolism. Vital intermediary steps are localized to mitochondria, but it remains unclear how one-carbon availability connects to mitochondrial function. Here, we show that the one-carbon metabolite and methyl group donor
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