Evidence map›Paper›PMID 33608076›Full record

ArticleAnalytica chimica acta2021

Utility of low-cost, miniaturized peristaltic and Venturi pumps in droplet microfluidics.

Joshua J Davis, Melanie Padalino, Alexander S Kaplitz, Greggory Murray, Samuel W Foster, Jonathan Maturano, James P Grinias

Abstract read
In one paragraph

Article in Analytica chimica acta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joshua J DavisDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, 08028, USA.
Melanie PadalinoDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, 08028, USA.
Alexander S KaplitzDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, 08028, USA.
Greggory MurrayDepartment of Mechanical Engineering, Rowan University, Glassboro, NJ, 08028, USA.
Samuel W FosterDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, 08028, USA.
Jonathan MaturanoDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, 08028, USA.
James P GriniasDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, 08028, USA. Electronic address: grinias@rowan.edu.

Funding

Portable Liquid Chromatography Platform for Diverse Pharmaceutical ApplicationsR44GM137649 · NIGMS · AXCEND, LLC · PI LEE, MILTON L. · 2020 to 2022
$1.7M
NIGMS NIH HHS R44 GM137649
6 · The paper itself

Abstract

Many laboratory applications utilizing droplet microfluidics rely on precision syringe pumps for flow generation. In this study, the use of an open-source peristaltic pump primarily composed of 3D printed parts and a low-cost commercial Venturi pump are explored for their use as an alternative to syringe pumps for droplet microfluidics. Both devices provided stable flow (<2% RSD) over a range of 1-7 μL/min and high reproducibility in signal intensity at a droplet generation rate around 0.25 Hz (<3% RSD), which are comparable in performance to similar measurements on standard syringe pumps. As a novel flow generation source for microfluidic applications, the use of the miniaturized Venturi pump was also applied to droplet signal monitoring studies used to measure changes in concentration over time, with average signal reproducibility <4% RSD for both single-stream fluorometric and reagent addition colorimetric applications. These low-cost flow methods provide stable flow sufficient for common droplet microfluidic approaches and can be implemented in a wide variety of simple, and potentially portable, analytical measurement devices.

Indexed as

3D printingLab-on-chipMicrofluidicsPeristaltic pumpSegmented flow dropletsVenturi pump

Identifiers

PMID33608076
PMCPMC7897340

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.