ArticleNutrition & metabolism2021
Fat mass to fat-free mass ratio and the risk of non-alcoholic fatty liver disease and fibrosis in non-obese and obese individuals.
Article in Nutrition & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Association of a novel Fat-Muscle-BMI Index (FMBI) with NAFLD, liver fibrosis, and atherosclerotic cardiovascular disease risk: a cross-sectional study in 1,592 Chinese adults.BMC gastroenterology · 2026Article
- Body Composition Changes After Bariatric Surgery or Treatment With GLP-1 Receptor Agonists.JAMA network open · 2026Article
- Association between predicted body composition and metabolic-associated fatty liver disease: a case-control study in a Chinese population.Frontiers in medicine · 2026Article
- Association between body composition and metabolic dysfunction-associated steatotic liver disease in Chinese general population: a cross-sectional study stratified by sex and obesity status.Frontiers in public health · 2026Article
- High adiposity linked to presarcopenia and decreased cardiorespiratory fitness in sedentary young Indians independent of their high-fat-salt-sugar (HFSS) food frequency.Scientific reports · 2025Article
- Relationship of fat mass index and fat free mass index with body mass index and association with sleeping patterns and physical activity in Saudi young adults women.Journal of health, population, and nutrition · 2025Article
- Effect of gold nanoparticles treatment on rats-induced obesity by evaluating body-composition directly and indirectly via bioelectric impedance analysis.Scientific reports · 2025Article
- The lean body mass to visceral fat mass ratio is negatively associated with cardiometabolic disorders: a cross-sectional study.Scientific reports · 2025Article
- Long-term outcomes and risk modifiers of metabolic dysfunction-associated steatotic liver disease between lean and non-lean populations.Clinical and molecular hepatology · 2025Review
- Ratio of fat-free mass to fat mass is associated with physical performance in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Body Composition in Cases with Normal Alanine Aminotransferase Values in Medical Health Checkups.Nutrients · 2024Article
- Regional fat distribution and hepatic fibrosis and steatosis severity in patients with nonalcoholic fatty liver disease and type 2 diabetes.Obesity science & practice · 2024Article
- Article
- Measurement of body composition in postpartum South African women living with and without HIV infection.Frontiers in nutrition · 2024Article
- Observational
- Sex- and reproductive status-specific relationships between body composition and non-alcoholic fatty liver disease.BMC gastroenterology · 2023Article
- High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters.Biomolecules · 2023Review
- Association between triglyceride-glucose index and nonalcoholic fatty liver disease in type 2 diabetes mellitus.BMC endocrine disorders · 2022Article
- Lower fitness levels, higher fat-to-lean mass ratios, and lower cardiorespiratory endurance are more likely to affect the body mass index of Saudi children and adolescents.Frontiers in public health · 2022Article
- Fat-to-Muscle Ratios and the Non-Achievement of LDL Cholesterol Targets: Analysis of the Korean Genome and Epidemiology Study.Journal of cardiovascular development and disease · 2021Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
contextBody composition may explain partially why non-obese individuals still at the risk of developing non-alcoholic fatty liver disease (NAFLD). The ratio of fat mass to fat-free mass (FM/FFM) has been proposed to assess the combined effect of different body compositions.
objectiveWe aimed to investigate the associations of FM/FFM ratio with the risk of developing NAFLD and fibrosis and to identify the potential mediators according to obesity status.
methodsThis cohort study comprised 3419 adults age ≥ 40 years and free of NAFLD at baseline. Body composition was measured by bioelectrical impedance analysis. NAFLD was ascertained by ultrasonography and fibrosis was assessed by non-invasive score systems.
resultsFor each 1 standard deviation increment in FM/FFM ratio, the odds ratio for the risk of NAFLD was 1.55 (95% confidence interval [CI] 1.23-1.95) in non-obese men, 1.33 (95% CI 1.08-1.65) in obese men, 1.42 (95% CI 1.44-1.67) in non-obese women, and 1.29 (95% CI 1.12-1.50) in obese women. Similar associations were also found between FM/FFM ratio and NAFLD with fibrosis. Mediation analysis showed that insulin resistance, triglycerides, high-density lipoprotein cholesterol, white blood cells, and total cholesterol mediated the association of FM/FFM ratio with NAFLD risk in specific sex and obesity subgroups.
conclusionsThe FM/FFM ratio significantly associated with the NAFLD and fibrosis risk in both non-obese and obese individuals. Different factors may mediate the association between body composition and NAFLD risk according to different obesity status.
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