ArticleEnvironmental health and preventive medicine2021
Lower albumin levels are associated with frailty measures, trace elements, and an inflammation marker in a cross-sectional study in Tanushimaru.
Article in Environmental health and preventive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Frailty and pituitary surgery: a systematic review.Pituitary · 2025Pooled it
- Preoperative Hypoalbuminemia as an Independent Predictor of Postoperative Acute Kidney Dysfunction After Cardiac Surgery.Annals of thoracic surgery short reports · 2026Article
- Contemporary real-world treatment of cardiac transthyretin amyloidosis with tafamidis: a long-term multicentre study.ESC heart failure · 2026Article
- Geriatric nutritional risk index and C-reactive protein: prognostic impact in transcatheter aortic valve implantation.Heart and vessels · 2026Article
- Article
- Physical frailty in relation to immunosenescence involving pDC function in the Japanese elderly: a cross-sectional survey study.Immunity & ageing : I & A · 2026Article
- C-reactive protein to albumin ratio as a predictor of early postoperative wound complications in patients undergoing posterior lumbar spine surgery.Frontiers in surgery · 2026Article
- Increased blood urea nitrogen to serum albumin ratio is associated with poor prognosis in patients with acute pancreatitis: a retrospective cohort study.Archives of medical science : AMS · 2026Article
- Frailty prediction in heart failure patients with acute infections: the potential role of thiazide diuretics?PloS one · 2026Article
- FINE, a novel laboratory-based frailty index for elderly patients: a retrospective descriptive study.Sao Paulo medical journal = Revista paulista de medicina · 2026Article
- Preoperative serum prealbumin as a prognostic marker for survival after gallbladder cancer resection: a multicenter study.BMC gastroenterology · 2025Article
- Association between gut microbiota dysbiosis and perioperative neurocognitive disorder and postoperative complications after valve replacement surgery: a prospective cohort study.BMC anesthesiology · 2025Article
- Nutritional status and frailty in elderly patients undergoing major abdominal surgery for upper gastrointestinal tumors: a single-center prospective observational study.Irish journal of medical science · 2025Observational
- Frailty and Cognitive Decline in Hospitalized Elderly Patients: Associations with Clinical and Laboratory Parameters.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Article
- Association Between Preoperative Frailty Using Frailty Index-Laboratory Test and Clinical Outcomes in Older Adults Undergoing Brain Tumor Surgery.Nursing & health sciences · 2025Article
- Frailty and malnutrition scores in predicting postoperative complications in minimally invasive prostatectomy for malignancy of the prostate.Journal of robotic surgery · 2025Article
- Development and Validation of a Risk Model to Predict Intraoperative Blood Transfusion.JAMA network open · 2025Article
- Real-world characteristics and treatment of cardiac transthyretin amyloidosis: A multicentre, observational study.ESC heart failure · 2025Observational
- Cross-sectional association between hs-CRP/HDL-C ratio and physical frailty among middle-aged and older adults: findings from a population-based study.Frontiers in public health · 2025Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere is little data on the association between the lower nutrition represented by serum albumin levels and related factors in a general population. The present study aimed to determine whether the albumin level positioned as some kind of biomarker with frailty measures, trace elements, and an inflammation marker.
methodsIn 2018, we performed an epidemiological survey in 1368 subjects who resided in Tanushimaru, Japan, in which we examined the blood chemistry including albumin, trace elements, hormone levels, and carotid ultrasonography. Albumin levels were categorized into 4 groups (G1 [3.2-3.9 mg/dL], G2 [4.0-4.3 mg/dL], G3 [4.4-4.6 mg/dL], and G4 [4.7-5.3 mg/dL]). The participants underwent measurements of handgrip strength and were tested by asking to walk 5 m. Their cognitive functions were evaluated by the mini-mental state examination (MMSE).
resultsMultiple stepwise regression analysis demonstrated that albumin levels were significantly and independently associated with age (inversely), systolic blood pressures, estimated glomerular filtration rate (eGFR), MMSE score, frailty measures (handgrip strength), an inflammation marker (high-sensitivity C-reactive protein), hormones (growth hormone (inversely) and insulin-like growth factor-1), and trace elements (calcium, magnesium, iron, and zinc), with a linear trend.
conclusionsLower albumin levels, even in the normal range, were found to be related factors of frailty measures, trace elements, and an inflammation marker in a general population.
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