ArticleThe Thoracic and cardiovascular surgeon2021
Lymphocyte Immune Response and T Cell Differentiation in Fontan Patients with protein-losing enteropathy.
Article in The Thoracic and cardiovascular surgeon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Risk Factors for Secondary Immunodeficiency in the Aged.The journal of allergy and clinical immunology. In practice · 2026Review
- Pediatric heart transplant survival in single ventricle disease.JHLT open · 2025Article
- Circulating Biomarkers in Failing Fontan Circulation: Current Evidence and Future Directions.Journal of cardiovascular development and disease · 2025Review
- Pre-Transplant Immunophenotyping in Pediatric Heart Transplant: A Role for the Immunologist?Pediatric transplantation · 2025Article
- Mulibrey nanism and immunological complications: a comprehensive case report and literature review.Frontiers in immunology · 2023Review
- Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio in Univentricular Patients From Birth to Follow-Up After Fontan-Predicting Lymphatic Abnormalities.Frontiers in pediatrics · 2021Article
- Evaluation of Immune System Components in Dogs With Protein-Losing Enteropathy Compared to Healthy Controls.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProtein-losing enteropathy (PLE) is a severe complication of the Fontan circulation. There is increasing discussion about whether lymphatic dysregulation is involved as pathomechanism of PLE. This investigation focuses on the interplay between alteration of lymphatic cells and immunologic pathway alterations.
methodsMicro-ribonucleic acid (miRNA) expression profiling was performed in 49 patients (
resultsmiRNAs pathway analysis of Fontan patients with PLE revealed 20 significantly changed networks of which four of the ten largest were associated with immunologic processes. This finding is supported by significant T cell deficiency with decreased CD4+ count (
conclusionPLE in Fontan patients is associated with severe lymphopenia, T cell deficiency, significant alterations of T cell differentiation, and increased Treg frequency reflecting an immune status of chronic inflammation and shortened protection against pathogens and autoimmunity. These cellular alterations seemed to be dysregulated by several miRNA controlled immunological pathways.
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Registered trials
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