ArticleNeuroImage2021
GABA levels are differentially associated with bimanual motor performance in older as compared to young adults.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- High-dose Vitamin-B6 reduces sensory over-responsivity.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Transcranial direct current stimulation enhances motor learning in Parkinson's disease: a randomized controlled trial.Journal of neurology · 2023Trial
- The role of inhibitory and excitatory neurometabolites in age-related differences in action selection.npj aging · 2025Article
- The Reciprocal Relationship Between Short- and Long-Term Motor Learning and Neurometabolites.Human brain mapping · 2025Article
- GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups.Frontiers in aging neuroscience · 2025Article
- Age-related GABA- and glutamatergic differences in SMA during bimanual coordination.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Rebalance the Inhibitory System in the Elderly Brain: Influence of Balance Learning on GABAergic Inhibition and Functional Connectivity.Human brain mapping · 2024Article
- MRS-assessed brain GABA modulation in response to task performance and learning.Behavioral and brain functions : BBF · 2024Review
- Baseline GABA+ levels in areas associated with sensorimotor control predict initial and long-term motor learning progress.Human brain mapping · 2024Article
- GABA, Aging and Exercise: Functional and Intervention Considerations.Neuroscience insights · 2024Review
- Unveiling MRI markers for Parkinson's Disease: GABAergic dysfunction and cortical changes.NeuroImage. Clinical · 2024Article
- Higher cognitive load interferes with head-hand coordination: virtual reality-based study.Scientific reports · 2023Article
- White matter and neurochemical mechanisms underlying age-related differences in motor processing speed.iScience · 2023Article
- Altered Bimanual Kinetic and Kinematic Motor Control Capabilities in Older Women.International journal of environmental research and public health · 2023Article
- Article
- The interaction between endogenous GABA, functional connectivity, and behavioral flexibility is critically altered with advanced age.Communications biology · 2022Article
- Task-Related Modulation of Sensorimotor GABA+ Levels in Association with Brain Activity and Motor Performance: A Multimodal MRS-fMRI Study in Young and Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Bimanual motor impairments in older adults: an updated systematic review and meta-analysis.EXCLI journal · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Although gamma aminobutyric acid (GABA) is of particular importance for efficient motor functioning, very little is known about the relationship between regional GABA levels and motor performance. Some studies suggest this relation to be subject to age-related differences even though literature is scarce. To clarify this matter, we employed a comprehensive approach and investigated GABA levels within young and older adults across multiple motor tasks as well as multiple brain regions. Specifically, 30 young and 30 older adults completed a task battery of three different bimanual tasks. Furthermore, GABA levels were obtained within bilateral primary sensorimotor cortex (SM1), bilateral dorsal premotor cortex, the supplementary motor area and bilateral dorsolateral prefrontal cortex (DLPFC) using magnetic resonance spectroscopy. Results indicated that older adults, as compared to their younger counterparts, performed worse on all bimanual tasks and exhibited lower GABA levels in bilateral SM1 only. Moreover, GABA levels across the motor network and DLPFC were differentially associated with performance in young as opposed to older adults on a manual dexterity and bimanual coordination task but not a finger tapping task. Specifically, whereas higher GABA levels related to better manual dexterity within older adults, higher GABA levels predicted poorer bimanual coordination performance in young adults. By determining a task-specific and age-dependent association between GABA levels across the cortical motor network and performance on distinct bimanual tasks, the current study advances insights in the role of GABA for motor performance in the context of aging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.