Evidence map›Paper›PMID 33607217›Full record

ArticleFree radical biology & medicine2021

N-acetyl-lysyltyrosylcysteine amide, a novel systems pharmacology agent, reduces bronchopulmonary dysplasia in hyperoxic neonatal rat pups.

Ru-Jeng Teng, Xigang Jing, Dustin P Martin, Neil Hogg, Aaron Haefke, Girija G Konduri, Billy W Day, Stephen Naylor, Kirkwood A Pritchard

Abstract read
In one paragraph

Article in Free radical biology & medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Molecular Approach of Oxidative Stress and Bronchopulmonary Dysplasia: Relationship of GSTM1 and GSTT1 Genes.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Cellular Senescence Contributes to the Progression of Hyperoxic Bronchopulmonary Dysplasia.American journal of respiratory cell and molecular biology · 2024
    Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ru-Jeng TengDivision of Neonatology, Department of Pediatrics, Medical College of Wisconsin, Wauwatosa, WI, USA.
Xigang JingDivision of Neonatology, Department of Pediatrics, Medical College of Wisconsin, Wauwatosa, WI, USA.
Dustin P MartinDivision of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA; ReNeuroGen LLC, Milwaukee, WI, USA.
Neil HoggDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.
Aaron HaefkeDivision of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Girija G KonduriDivision of Neonatology, Department of Pediatrics, Medical College of Wisconsin, Wauwatosa, WI, USA.
Billy W DayReNeuroGen LLC, Milwaukee, WI, USA.
Stephen NaylorReNeuroGen LLC, Milwaukee, WI, USA.
Kirkwood A PritchardDivision of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA; ReNeuroGen LLC, Milwaukee, WI, USA. Electronic address: kpritch@mcw.edu.

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
Mechanisms of Inflammation in Sickle Cell DiseaseR01HL128371 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI PRITCHARD, KIRKWOOD ARTHUR · 2016 to 2024
$4.2M
BH4 in hyperoxic lung injury in newbornR03HD073274 · NICHD · MEDICAL COLLEGE OF WISCONSIN · PI TENG, RU-JENG · 2012 to 2013
$149k
NCATS NIH HHS UL1 TR001436NHLBI NIH HHS R01 HL128371NICHD NIH HHS R03 HD073274
6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD) is caused primarily by oxidative stress and inflammation. To induce BPD, neonatal rat pups were raised in hyperoxic (>90% O

Indexed as

Bronchopulmonary DysplasiaHyperoxiaAmidesAnimalsAnimals, NewbornHumansHydrogen PeroxideInfant, NewbornKelch-Like ECH-Associated Protein 1LungNF-E2-Related Factor 2RatsAmidesHydrogen PeroxideKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Bronchopulmonary dysplasiaHigh mobility group box-1Kelch-like ECH-Associated protein 1MyeloperoxidaseNuclear factor erythroid 2-related factor 2

Identifiers

PMID33607217
PMCPMC8009865

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.