Evidence map›Paper›PMID 33607182›Full record

ReviewNeuroscience and biobehavioral reviews2021

Markov blankets in the brain.

Inês Hipólito, Maxwell J D Ramstead, Laura Convertino, Anjali Bhat, Karl Friston, Thomas Parr

Abstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The myth of the Bayesian brain.European journal of applied physiology · 2025
    Review
  9. Five Fristonian Formulae.Entropy (Basel, Switzerland) · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Inês HipólitoHumboldt-Universität zu Berlin, Department of Philosophy & Berlin School of Mind and Brain, Germany; Wellcome Centre for Human Neuroimaging, University College London, United Kingdom. Electronic address: ines.hipolito@hu-berlin.de.
Maxwell J D RamsteadWellcome Centre for Human Neuroimaging, University College London, United Kingdom; Division of Social and Transcultural Psychiatry, Department of Psychiatry, McGill University, Montreal, Quebec, Canada; Culture, Mind, and Brain Program, McGill University, Montreal, Quebec, Canada.
Laura ConvertinoWellcome Centre for Human Neuroimaging, University College London, United Kingdom; Institute of Cognitive Neuroscience (ICN), University College London, London, United Kingdom.
Anjali BhatWellcome Centre for Human Neuroimaging, University College London, United Kingdom.
Karl FristonWellcome Centre for Human Neuroimaging, University College London, United Kingdom.
Thomas ParrWellcome Centre for Human Neuroimaging, University College London, United Kingdom.

Funding

Medical Research Council D79/543369/D-OTH/170890Wellcome TrustWellcome Trust 088130/Z/09/Z
6 · The paper itself

Abstract

Recent characterisations of self-organising systems depend upon the presence of a 'Markov blanket': a statistical boundary that mediates the interactions between the inside and outside of a system. We leverage this idea to provide an analysis of partitions in neuronal systems. This is applicable to brain architectures at multiple scales, enabling partitions into single neurons, brain regions, and brain-wide networks. This treatment is based upon the canonical micro-circuitry used in empirical studies of effective connectivity, so as to speak directly to practical applications. The notion of effective connectivity depends upon the dynamic coupling between functional units, whose form recapitulates that of a Markov blanket at each level of analysis. The nuance afforded by partitioning neural systems in this way highlights certain limitations of 'modular' perspectives of brain function that only consider a single level of description.

Indexed as

BrainBrain MappingHumansBoundariesCanonical microcircuitDynamic causal modellingMarkov blankets

Identifiers

PMID33607182
PMCPMC8373616

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.