Evidence map›Paper›PMID 33607172›Full record

ArticleMechanisms of ageing and development2021

Genome-wide association analysis of cognitive function in Danish long-lived individuals.

Marianne Nygaard, Joseph Dowsett, Matt McGue, Kaare Christensen, Lene Christiansen, Qihua Tan, Jonas Mengel-From

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mechanisms of ageing and development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  5. Pleiotropic Effects ofBiomolecules · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Marianne NygaardThe Danish Twin Registry and The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, J.B. Winsloews Vej 9B, 5000 Odense C, Denmark; Department of Clinical Genetics, Odense University Hospital, J.B. Winsloews Vej 4, 5000 Odense C, Denmark. Electronic address: mnygaard@health.sdu.dk.
Joseph DowsettThe Danish Twin Registry and The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, J.B. Winsloews Vej 9B, 5000 Odense C, Denmark; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen OE, Denmark.
Matt McGueThe Danish Twin Registry and The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, J.B. Winsloews Vej 9B, 5000 Odense C, Denmark; Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, USA.
Kaare ChristensenThe Danish Twin Registry and The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, J.B. Winsloews Vej 9B, 5000 Odense C, Denmark; Department of Clinical Genetics, Odense University Hospital, J.B. Winsloews Vej 4, 5000 Odense C, Denmark; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Kløvervænget 47, 5000 Odense C, Denmark.
Lene ChristiansenThe Danish Twin Registry and The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, J.B. Winsloews Vej 9B, 5000 Odense C, Denmark; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen OE, Denmark.
Qihua TanThe Danish Twin Registry and The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, J.B. Winsloews Vej 9B, 5000 Odense C, Denmark; Department of Clinical Genetics, Odense University Hospital, J.B. Winsloews Vej 4, 5000 Odense C, Denmark.
Jonas Mengel-FromThe Danish Twin Registry and The Danish Aging Research Center, Department of Public Health, University of Southern Denmark, J.B. Winsloews Vej 9B, 5000 Odense C, Denmark; Department of Clinical Genetics, Odense University Hospital, J.B. Winsloews Vej 4, 5000 Odense C, Denmark.
University of Southern Denmark · DKUniversity of Minnesota · US

Funding

TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI YASHIN, ANATOLIY I · 1990 to 2008
$17.5M
NIA NIH HHS P01 AG008761
6 · The paper itself

Abstract

Cognitive function is a substantially heritable trait related to numerous important life outcomes. Several genome-wide association studies of cognitive function have in recent years led to the identification of thousands of significantly associated loci and genes. Individuals included in these studies have rarely been nonagenarians and centenarians, and since cognitive function is an important component of quality of life for this rapidly expanding demographic group, there is a need to explore genetic factors associated with individual differences in cognitive function at advanced ages. In this study, we pursued this by performing a genome-wide association study of cognitive function in 490 long-lived Danes (age range 90.1-100.8 years). While no genome-wide significant SNPs were identified, suggestively significant SNPs (P < 1 × 10

Indexed as

Quality of LifeAged, 80 and overAxonemal DyneinsCELF ProteinsCell CycleCognitionCognitive AgingDenmarkFemaleGenetic Association StudiesGenome-Wide Association StudyHumansIntracellular Signaling Peptides and ProteinsMaleNerve Tissue ProteinsNuclear ProteinsAxonemal DyneinsCELF2 protein, humanCELF ProteinsDNAH5 protein, humanIntracellular Signaling Peptides and ProteinsNerve Tissue ProteinsNuclear ProteinsZWINT protein, humanCognitive functionGene-based analysisGenome-wide association studyLong-lived individualsPathway analysis

Identifiers

PMID33607172
PMCPMC8035220
OpenAlexW3132457982

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.