Evidence map›Paper›PMID 33607163›Full record

ArticleBehavioural brain research2021

Comparison of memory, affective behavior, and neuropathology in APP

Andrea Locci, Hector Orellana, Guadalupe Rodriguez, Meredith Gottliebson, Bryan McClarty, Sky Dominguez, Rachel Keszycki, Hongxin Dong

Open access · greenAbstract readComparative Study
In one paragraph

Article in Behavioural brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 65 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Andrea LocciDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Hector OrellanaDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Guadalupe RodriguezDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Meredith GottliebsonDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Bryan McClartyDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Sky DominguezDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Rachel KeszyckiDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Hongxin DongDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. Electronic address: h-dong@northwestern.edu.
Northwestern University · US

Funding

Molecular Mechanisms Underlying Behavioral and Psychological Symptoms in Alzheimers DiseaseR01AG062249 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DONG, HONGXIN, WILSON, ROBERT S · 2018 to 2022
$3.5M
Sex Differences in Central Stress Response and Alzheimer's Disease NeuropathologyRF1AG057884 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DONG, HONGXIN · 2017 to 2019
$2.1M
Age-Related Histone Modification Effect on Antipsychotic ActionR01MH109466 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DONG, HONGXIN · 2016 to 2020
$2.1M
Stress and Sexuality Divergent Neuropathy in Alzheimer's DiseaseR56AG053491 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DONG, HONGXIN · 2016 to 2016
$414k
NIA NIH HHS R01 AG062249NIA NIH HHS R56 AG053491NIA NIH HHS RF1 AG057884NIMH NIH HHS R01 MH109466
6 · The paper itself

Abstract

Transgenic mouse models of Aβ amyloidosis generated by knock-in of a humanized Aβ sequence can offer some advantages over the transgenic models that overexpress amyloid precursor protein (APP). However, systematic comparison of memory, behavioral, and neuropathological phenotypes between these models has not been well documented. In this study, we compared memory and affective behavior in APP

Indexed as

AffectMemoryAmyloid beta-Protein PrecursorAnimalsBrainFemaleLocomotionMaleMemory, Short-TermMiceMice, Inbred C57BLMice, TransgenicMorris Water Maze TestOligopeptidesOpen Field TestSocial InteractionAmyloid beta-Protein PrecursorAPP protein, humanOligopeptidesPS1 antigenAffective behaviorAlzheimer’s diseaseAPP(NLGF)Aβ plaquesMemoryMouse model

Identifiers

PMID33607163
PMCPMC7980131
OpenAlexW3129933261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.