ArticleThe American journal of pathology2021
Unbound Corneocyte Lipid Envelopes in 12R-Lipoxygenase Deficiency Support a Specific Role in Lipid-Protein Cross-Linking.
Article in The American journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Metabolomics reveals pro-inflammatory effects of 12R-HETE and ALOX12B in maternal allergic asthma.Communications biology · 2025Article
- Nonsense Variant in CYP4F22 Causes Malformation of Corneocyte Lipid Envelopes in a Lamellar Ichthyosis Patient.Acta dermato-venereologica · 2025Article
- Environmental pro-oxidants induce altered envelope protein profiles in human keratinocytes.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- ω-O-Acylceramides but not ω-hydroxy ceramides are required for healthy lamellar phase architecture of skin barrier lipids.Journal of lipid research · 2022Article
- Woodsmoke Extracts Cross-Link Proteins and Induce Cornified Envelope Formation without Stimulating Keratinocyte Terminal Differentiation.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Loss-of-function mutations in arachidonate lipoxygenase 12B (ALOX12B) are an important cause of autosomal recessive congenital ichthyosis (ARCI). 12R-lipoxygenase (12R-LOX), the protein product of ALOX12B, has been proposed to covalently bind the corneocyte lipid envelope (CLE) to the proteinaceous corneocyte envelope, thereby providing a scaffold for the assembly of barrier-providing, mature lipid lamellae. To test this hypothesis, an in-depth ultrastructural examination of CLEs was performed in ALOX12B
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Registered trials
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