ArticleCurrent biology : CB2021
Neural processing of the reward value of pleasant odorants.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Brain-Wide Activations Related to Forepaw Force Control Identified by Behaving Mouse FMRI.eNeuro · 2026Article
- Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system.PLoS biology · 2026Article
- Separable and integrated pleasantness coding for appetitive and aversive odors across olfactory and ventral prefrontal cortices.Nature communications · 2026Article
- Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose 'liking'.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose 'liking'.bioRxiv : the preprint server for biology · 2025Article
- A midbrain-to-ventral-striatum dopaminergic pathway orchestrates odor-guided insect predation in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Brain-wide organization of intrinsic timescales at single-neuron resolution.bioRxiv : the preprint server for biology · 2025Article
- Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior.Nature communications · 2025Article
- Optimized workflow for behavior-coupled fiber photometry experiment: improved data navigation and accessibility.Frontiers in neuroscience · 2025Article
- Valproate Administration to Adult 5xFAD Mice Upregulates Expression of Neprilysin and Improves Olfaction and Memory.Journal of molecular neuroscience : MN · 2024Article
- The human olfactory bulb communicates perceived odor valence to the piriform cortex in the gamma band and receives a refined representation back in the beta band.PLoS biology · 2024Article
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Structural Connectivity between Olfactory Tubercle and Ventrolateral Periaqueductal Gray Implicated in Human Feeding Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- An experimental framework for conjoint measures of olfaction, navigation, and motion as pre-clinical biomarkers of Alzheimer's disease.Journal of Alzheimer's disease reports · 2024Review
- Endogenous opioids in the olfactory tubercle and their roles in olfaction and quality of life.Frontiers in neural circuits · 2024Review
- Combining pleasant Olfactory and BRAin stimulations in treatment-resistant depression (COBRA): study protocol for a randomized controlled trial.Frontiers in psychology · 2024Article
- Chronic unpredictable mild stress alters odor hedonics and adult olfactory neurogenesis in mice.Frontiers in neuroscience · 2023Article
- Potential neural substrates underlying circadian and olfactory disruptions in preclinical Alzheimer's disease.Frontiers in neuroscience · 2023Review
- Odour hedonics and the ubiquitous appeal of vanilla.Nature food · 2022Review
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17 authors at 6 institutions in 2 countries.
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Abstract
Pleasant odorants are represented in the posterior olfactory bulb (pOB) in mice. How does this hedonic information generate odor-motivated behaviors? Using optogenetics, we report here that stimulating the representation of pleasant odorants in a sensory structure, the pOB, can be rewarding, self-motivating, and is accompanied by ventral tegmental area activation. To explore the underlying neural circuitry downstream of the olfactory bulb (OB), we use 3D high-resolution imaging and optogenetics and determine that the pOB preferentially projects to the olfactory tubercle, whose increased activity is related to odorant attraction. We further show that attractive odorants act as reinforcers in dopamine-dependent place preference learning. Finally, we extend those findings to humans, who exhibit place preference learning and an increase BOLD signal in the olfactory tubercle in response to attractive odorants. Thus, strong and persistent attraction induced by some odorants is due to a direct gateway from the pOB to the reward system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.