ReviewThe Lancet. Infectious diseases2021
Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology.
Erratum issuedOpen access · greenAbstract readReview
In one paragraph
Review in The Lancet. Infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 272 papers.
0numbers the graph read from it
0cells of the map it votes in
272citing papers in PubMed
18.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
272 citing papers in PubMed, 411 citations in OpenAlex.
- Evaluation of the cytochrome P450-mediated drug interaction profile of olorofim.Antimicrobial agents and chemotherapy · 2026Trial
- Fosmanogepix for the Treatment of Invasive Mold Diseases Caused by Aspergillus Species and Rare Molds: A Phase 2, Open-Label Study (AEGIS).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Trial
- Novel model to predict risk of invasive fungal infection and fungal prophylaxis timing.Microbiology spectrum · 2025Trial
- From misdiagnosis to precision management: Thoracic vertebral infection caused byMedical mycology case reports · 2026Article
- First report of proven Fusarium brachygibbosum sinusitis in a paediatric patient with acute myeloblastic leukaemia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Phaeohyphomycosis in a Solid Organ Transplant Recipient: Case Report of a New Pathogenic Species of Kirschsteiniothelia.Mycopathologia · 2026Article
- Performance of the Sensititre YeastOne assay compared with EUCAST E.Def 9.4 againstJAC-antimicrobial resistance · 2026Article
- The Brief Case: Recalcitrant cutaneous and subcutaneous knee infection caused byJournal of clinical microbiology · 2026Review
- Establishment of epidemiological cutoff values againstJournal of clinical microbiology · 2026Article
- Migratory Pulmonary Infiltrates Mimicking Malignancy, Tuberculosis, and Sarcoidosis in an Apparently Immunocompetent Adult: A Case of Tissue-Proven Invasive Fungal Disease Due to a Non-Journal of fungi (Basel, Switzerland) · 2026Article
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- Non-Candida fungal cholecystitis - an uncommon occurrence even in the right host.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Therapeutic Failure in Invasive Fungal Infections: Beyond Antifungal Resistance-A Narrative Review.Journal of fungi (Basel, Switzerland) · 2026Review
- 30 years in service, 1996-2026: Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).Annals of hematology · 2026Review
- Asian consensus on diagnostic algorithm for invasive pulmonary fungal diseases in high-burden settings.Journal of translational internal medicine · 2026Article
- Molecular Mechanisms, Diagnosis, and Therapeutic Strategies of Antifungal Resistance in Filamentous Fungi.Journal of fungi (Basel, Switzerland) · 2026Review
- MYcology Stewardship Tool (MyST): a retrospective, descriptive multidisciplinary team review of antifungal prescribing practice in a UK tertiary centre.JAC-antimicrobial resistance · 2026Article
- Fungal diagnostics and antifungal drug access in Latin America and the Caribbean: an ESCMID EFISG multinational survey.Nature communications · 2026Article
- Diagnostic Failure in Invasive Fungal Infections: Causes, Clinical Consequences, and Mitigation Strategies.Journal of fungi (Basel, Switzerland) · 2026Review
212 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
45 authors at 20 institutions in 24 countries.
Martin HoeniglSection of Infectious Diseases and Tropical Medicine, Medical University of Graz, Graz, Austria; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, CA, USA; Clinical and Translational Fungal Research Working Group, University of California San Diego, San Diego, CA, USA; European Confederation of Medical Mycology Council, Basel, Switzerland. Electronic address: hoeniglmartin@gmail.com.
Jon Salmanton-GarcíaFaculty of Medicine, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.
Thomas J WalshDepartment of Medicine, Department of Pediatrics, and Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA; New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA.
Marcio NucciDepartment of Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Chin Fen NeohFaculty of Pharmacy, and Collaborative Drug Discovery Research Group, Pharmaceutical and Life Sciences, Community of Research, Universiti Teknologi MARA, Selangor, Malaysia.
Jeffrey D JenksDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, CA, USA; Clinical and Translational Fungal Research Working Group, University of California San Diego, San Diego, CA, USA; Division of General Internal Medicine, Department of Medicine, University of California San Diego, San Diego, CA, USA.
Michaela LacknerInstitute of Hygiene and Medical Microbiology, Department of Hygiene, Medical Microbiology and Publics Health, Medical University Innsbruck, Innsbruck, Austria.
Rosanne SpruteFaculty of Medicine, University of Cologne, Cologne, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Cologne, Germany.
Abdullah M S Al-HatmiDepartment of Microbiology, Natural & Medical Sciences Research Center, University of Nizwa, Nizwa, Oman.
Matteo BassettiDivision of Infections Diseases, Department of Health Sciences, IRCCS San Martino Polyclinic Hospital, University of Genoa, Genoa, Italy.
Fabianne CarlesseDepartment of Pediatrics, and Pediatric Oncology Institute IOP-GRAACC-UNIFESP, Federal Univeristy of São Paulo, São Paulo, Brazil.
Tomas FreibergerCentre for Cardiovascular Surgery and Transplantation, and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Philipp KoehlerFaculty of Medicine, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Cologne, Germany; Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany.
Thomas LehrnbecherDivision of Pediatric Hematology and Oncology, Hospital for Children and Adolescents, University Hospital, Frankfurt, Germany.
Anil KumarDepartment of Microbiology, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, India.
Juergen PrattesSection of Infectious Diseases and Tropical Medicine, Medical University of Graz, Graz, Austria.
Malcolm RichardsonDivision of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK; Mycology Reference Centre Manchester, Manchester University NHS Foundation Trust, Manchester, UK.
Sanjay RevankarDivision of Infectious Diseases, Wayne State University, Detroit, MI, USA.
Monica A SlavinUniversity of Melbourne, Melbourne, VIC, Australia; National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Jannik StemlerFaculty of Medicine, University of Cologne, Cologne, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Cologne, Germany.
Birgit SpiessDepartment of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Saad J Taj-AldeenDepartment of Laboratory Medicne and Pathology, Hamad Medical Corporation, Doha, Qatar.
Adilia WarrisMedical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK.
Patrick C Y WooDepartment of Microbiology, University of Hong Kong, Hong Kong, China.
Jo-Anne H YoungUniversity of Minnesota, Minneapolis, MN, USA.
Kerstin AlbusFaculty of Medicine, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.
Dorothee ArenzFaculty of Medicine, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany; Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.
Valentina Arsic-ArsenijevicNational Reference Laboratory for Medical Mycology, Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; European Confederation of Medical Mycology Council, Basel, Switzerland.
Jean-Philippe BoucharaHost-Pathogen Interaction Study Group, and Laboratory of Parasitology and Mycology, Angers University Hospital, Angers University, Angers, France.
Terrence Rohan ChinniahDepartment of Microbiology, University of Colombo, Colombo, Sri Lanka.
Anuradha ChowdharyDepartment of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
G Sybren de HoogCenter of Expertise in Mycology, Radboud University Medical Center-Canisius Wilhelmina Hospital, Nijmegen, Netherlands.
George DimopoulosCritical Care Department, Attikon University Hospital, National and Kapodistrian University of Athens, Greece.
Rafael F DuarteUniversity Hospital Puerta de Hierro Majadahonda, Madrid, Spain.
Petr HamalDepartment of Microbiology, Faculty of Medicine and Dentistry, University Hospital Olomouc, Palacky University Olomouc, Olomouc, Czech Republic; European Confederation of Medical Mycology Council, Basel, Switzerland.
Jacques F MeisDepartment of Medical Microbiology and Infectious Diseases, Radboud University Medical Center-Canisius Wilhelmina Hospital, Nijmegen, Netherlands; Center of Expertise in Mycology, Radboud University Medical Center-Canisius Wilhelmina Hospital, Nijmegen, Netherlands; European Confederation of Medical Mycology Council, Basel, Switzerland.
Sayoki MfinangaNational Institute for Medical Research, Tanzania; Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania; Department of International Public Health, Liverpool School of Tropical Medicine, Liverpool, UK.
Flavio Queiroz-TellesDepartment of Public Health, Clinics Hospital, Federal University of Parana, Curitiba, Brazil.
Thomas F PattersonUT Health San Antonio and South Texas Veterans Health Care System, San Antonio, TX, USA.
Galia RahavSheba Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Thomas R RogersDepartment of Clinical Microbiology, Trinity College Dublin, St James's Hospital Campus, Dublin, Ireland.
Coleman RotsteinDivision of Infectious Diseases, University of Toronto, Toronto, ON, Canada.
Retno WahyuningsihDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta, Indonesia.
Danila SeidelFaculty of Medicine, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Cologne, Germany.
Oliver A CornelyFaculty of Medicine, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany; Clinical Trials Center Cologne, University of Cologne, Cologne, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Cologne, Germany; European Confederation of Medical Mycology Council, Basel, Switzerland.
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · DEUniversity of Cologne · DEMedical University of Graz · ATAmrita Institute of Medical Sciences and Research Centre · INGerman Center for Infection Research · DEGoethe University Frankfurt · DEHamad Medical Corporation · QAHeidelberg University · DEHospital de Clínicas Universidade Federal do Paraná · BRHospital Universitario Puerta de Hierro Majadahonda · ESInnsbruck Medical University · ATManchester University NHS Foundation Trust · GBMasaryk University · CZMedical Research Council · GBNational and Kapodistrian University of Athens · GRNelson Mandela African Institution of Science and Technology · TZOspedale Policlinico San Martino · ITPalacký University Olomouc · CZPeter MacCallum Cancer Centre · AUPresbyterian Hospital · US
Funding
Medical Research Council MR/N006364/2Medical Research Council MR/V033417/1
Abstract
With increasing numbers of patients needing intensive care or who are immunosuppressed, infections caused by moulds other than Aspergillus spp or Mucorales are increasing. Although antifungal prophylaxis has shown effectiveness in preventing many invasive fungal infections, selective pressure has caused an increase of breakthrough infections caused by Fusarium, Lomentospora, and Scedosporium species, as well as by dematiaceous moulds, Rasamsonia, Schizophyllum, Scopulariopsis, Paecilomyces, Penicillium, Talaromyces and Purpureocillium species. Guidance on the complex multidisciplinary management of infections caused by these pathogens has the potential to improve prognosis. Management routes depend on the availability of diagnostic and therapeutic options. The present recommendations are part of the One World-One Guideline initiative to incorporate regional differences in the epidemiology and management of rare mould infections. Experts from 24 countries contributed their knowledge and analysed published evidence on the diagnosis and treatment of rare mould infections. This consensus document intends to provide practical guidance in clinical decision making by engaging physicians and scientists involved in various aspects of clinical management. Moreover, we identify areas of uncertainty and constraints in optimising this management.
Indexed as
AnimalsDisease ManagementFungiHumansMycologyMycosesPractice Guidelines as TopicSocieties, Medical
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