ArticleStem cell reports2021
Novel Lineage-Tracing System to Identify Site-Specific Ectopic Bone Precursor Cells.
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Article in Stem cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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0cells of the map it votes in
23citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Dietary omega-6 lipids promote postinjury aberrant bone formation in obesity.The Journal of clinical investigation · 2026Article
- Clec3bBone research · 2026Article
- VEGF-D-induced intraosseous lymphangiogenesis drives site-specific heterotopic bone resorption.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization.Bone research · 2026Article
- Elucidating the Mechanism of Radiation Therapy on Mesenchymal Cell Fate in Preventing Heterotopic Ossification.Annals of surgery · 2025Article
- PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration.Nature communications · 2025Article
- Integrated transcriptomic analysis reveals evolutionary and developmental characteristics of tendon ossification in teleost.BMC biology · 2024Article
- Spatiotemporal Analysis of Mesenchymal Stem Cells Fate Determination by Inflammatory Niche Following Soft Tissue Injury at a Single-Cell Level.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Rankl genetic deficiency and functional blockade undermine skeletal stem and progenitor cell differentiation.Stem cell research & therapy · 2024Article
- The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair.Bone research · 2024Article
- Itaconate-producing neutrophils regulate local and systemic inflammation following trauma.JCI insight · 2023Article
- Tppp3Bone research · 2023Article
- Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization.Science advances · 2022Article
- Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell-cell interactions underlying the bone repair process.Regenerative therapy · 2022Article
- CTR9 drives osteochondral lineage differentiation of human mesenchymal stem cells via epigenetic regulation of BMP-2 signaling.Science advances · 2022Article
- Single-cell mapping of regenerative and fibrotic healing responses after musculoskeletal injury.Stem cell reports · 2022Article
- Functional Heterogeneity of Bone Marrow Mesenchymal Stem Cell Subpopulations in Physiology and Pathology.International journal of molecular sciences · 2022Review
- Contemporary perspectives on heterotopic ossification.JCI insight · 2022Review
- Pathophysiology and Emerging Molecular Therapeutic Targets in Heterotopic Ossification.International journal of molecular sciences · 2022Review
- Single-Cell Analyses of Heterotopic Ossification: Characteristics of Injury-Related Senescent Fibroblasts.Journal of inflammation research · 2022Article
Corrections and comments
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Authors and funding
23 authors at 5 institutions in 1 country.
Chase A PaganiCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, 6000 Harry Hines Boulevard, Dallas, TX 75235, USA.
Amanda K HuberSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Charles HwangSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Simone MariniSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Karthik PadmanabhanBRCF Epigenomics Core, University of Michigan, Ann Arbor, MI 48109, USA.
Nicholas LivingstonCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, 6000 Harry Hines Boulevard, Dallas, TX 75235, USA.
Johanna NunezCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, 6000 Harry Hines Boulevard, Dallas, TX 75235, USA.
Yuxiao SunCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, 6000 Harry Hines Boulevard, Dallas, TX 75235, USA.
Nicole EdwardsSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Yu-Hao ChengInstitute for Cell Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Noelle VisserSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Pauline YuSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Nicole PatelSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Joseph A GreensteinSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Husain RasheedSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Reagan NelsonSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Karen KesselSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Kaetlin VasquezSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Amy L StrongSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Geoffrey E HespeSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Jane Y SongDepartment of Cell and Regenerative Biology, University of Wisconsin, Madison, WI 53705, USA.
Deneen M WellikDepartment of Cell and Regenerative Biology, University of Wisconsin, Madison, WI 53705, USA.
Benjamin LeviCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, 6000 Harry Hines Boulevard, Dallas, TX 75235, USA. Electronic address: benjamin.levi@utsouthwestern.edu.
University of Michigan · USOrganogenesis (United States) · USUniversity of Wisconsin–Madison · USJohns Hopkins University · USSouthwestern Medical Center · US
Funding
Role of Hox Genes in Integration of the Musculoskeletal System in Development R01AR061402 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI WELLIK, DENEEN M · 2011 to 2021
$3.3MTargeting Molecular and Cellular Mediators of Inflammation to Prevent Pathologic Cell Differentiation and Heterotopic OssificationR01AR071379 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2017 to 2021
$1.5MDeveloping New Diagnostic and Timed, TAK1 Specific Treatment Strategies for Trauma Induced Heterotopic OssificationR01GM123069 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2017 to 2020
$1.2MNIAMS NIH HHS R01 AR061402NIAMS NIH HHS R01 AR071379NIGMS NIH HHS R01 GM123069
Abstract
Heterotopic ossification (HO) is a form of pathological cell-fate change of mesenchymal stem/precursor cells (MSCs) that occurs following traumatic injury, limiting range of motion in extremities and causing pain. MSCs have been shown to differentiate to form bone; however, their lineage and aberrant processes after trauma are not well understood. Utilizing a well-established mouse HO model and inducible lineage-tracing mouse (Hoxa11-CreER
Indexed as
Cell DifferentiationCell LineageOsteogenesisAdipocytesAnimalsBone and BonesChondrocytesDisease Models, AnimalEctopic Gene ExpressionEpigenomicsFemaleGene Expression ProfilingHomeodomain ProteinsMaleMesenchymal Stem CellsMiceHomeodomain ProteinsHoxa11 protein, mouseaberrant differentiationheterotopic ossificationHoxa11mesenchymal progenitorstendon
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.