Evidence map›Paper›PMID 33606955›Full record

ReviewAnnual review of biochemistry2021

Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis.

Mark von Zastrow, Alexander Sorkin

Abstract readReview
In one paragraph

Review in Annual review of biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Small-molecule CBLB inhibitor abolishes EGFR ubiquitination, reduces receptor endocytosis, and diminishes cell motility signaling.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Single-Molecule FRET-Tracking of InlB-Activated MET Receptors in Living Cells.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mark von ZastrowDepartment of Psychiatry, University of California, San Francisco, California 94143, USA; email: mark@vzlab.org.
Alexander SorkinDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA; email: sorkin@pitt.edu.

Funding

Regulation of Dopamine Transporter by TraffickingR01DA014204 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALEXANDER D SORKIN · 2001 to 2026
$8.3M
PROTEINS REGULATING ENDOCYTOSIS OF OPIOID RECEPTORSR01DA012864 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mark E Von Zastrow · 2000 to 2026
$7.9M
PATHOGENESIS OF CANCER--ROLE OF EGF RECEPTOR ENDOCYTOSISR01CA089151 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SORKIN, ALEXANDER D · 2001 to 2023
$6.9M
Membrane Trafficking of Opioid and Adrenergic ReceptorsR01DA010711 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VONZASTROW, MARK E · 2014 to 2023
$4.6M
Multiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolutionU01NS120820 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN, VONZASTROW, MARK E · 2021 to 2024
$3.5M
GPR88 localization to primary cilia and its impact on striatal cAMP signalingR01MH120212 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VONZASTROW, MARK E · 2019 to 2023
$2.0M
Signaling by the EGF Receptor from EndosomesR01GM124186 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SORKIN, ALEXANDER D · 2017 to 2021
$1.6M
NCI NIH HHS R01 CA089151NIDA NIH HHS R01 DA010711NIDA NIH HHS R01 DA012864NIDA NIH HHS R01 DA014204NIGMS NIH HHS R01 GM124186NIMH NIH HHS R01 MH120212NINDS NIH HHS U01 NS120820
6 · The paper itself

Abstract

Intricate relationships between endocytosis and cellular signaling, first recognized nearly 40 years ago through the study of tyrosine kinase growth factor receptors, are now known to exist for multiple receptor classes and to affect myriad physiological and developmental processes. This review summarizes our present understanding of how endocytosis orchestrates cellular signaling networks, with an emphasis on mechanistic underpinnings and focusing on two receptor classes-tyrosine kinase and G protein-coupled receptors-that have been investigated in particular detail. Together, these examples provide a useful survey of the current consensus, uncertainties, and controversies in this rapidly advancing area of cell biology.

Indexed as

AnimalsCell MembraneEndocytosisEndosomesHumansLysosomesProtein TransportReceptor Protein-Tyrosine KinasesReceptors, G-Protein-CoupledSignal TransductionReceptor Protein-Tyrosine KinasesReceptors, G-Protein-CoupleddownregulationendocytosisendosomesG protein–coupled receptorsreceptor tyrosine kinasessignaling

Identifiers

PMID33606955
PMCPMC8608402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.