Evidence map›Paper›PMID 33606889›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Re

Johannes Karges, Mark Kalaj, Milan Gembicky, Seth M Cohen

Erratum issuedAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Tricarbonyl Rhenium-Based PROTACs Degrade the SARS-CoV-2 Mpro Protease.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Article
  3. Synthesis of aACS omega · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Metallo-antiviral aspirants:European journal of medicinal chemistry reports · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Potential medicinal plants involved in inhibiting 3CLJournal of integrative medicine · 2022
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Johannes KargesDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-5258-0260
Mark KalajDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-7139-7517
Milan GembickyDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
Seth M CohenDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-5233-2280

Funding

Metallofragments as 3-Dimensional Scaffolds for Fragment-Based Drug DiscoveryR21AI138934 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THEODORAKIS, EMMANUEL A · 2018 to 2019
$402k
NIAID NIH HHS R21 AI138934
6 · The paper itself

Abstract

Since its outbreak, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has impacted the quality of life and cost hundreds-of-thousands of lives worldwide. Based on its global spread and mortality, there is an urgent need for novel treatments which can combat this disease. To date, the 3-chymotrypsin-like protease (3CL

Indexed as

COVID-19 Drug TreatmentAntiviral AgentsCoordination ComplexesCoronavirus 3C ProteasesDrug DiscoveryHumansModels, MolecularProtease InhibitorsRheniumSARS-CoV-23C-like proteinase, SARS-CoV-2Antiviral AgentsCoordination ComplexesCoronavirus 3C ProteasesProtease InhibitorsRheniumantiviral agentsbioinorganic chemistrymedicinal inorganic chemistryprotease inhibitorSARS-CoV-2

Identifiers

PMID33606889
PMCPMC8014511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.