ArticlePloS one2021
Associations between probable REM sleep behavior disorder, olfactory disturbance, and clinical symptoms in Parkinson's disease: A multicenter cross-sectional study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 31 citations in OpenAlex.
- Evaluating the Relationship Between Early Non-Motor Symptoms and Late Diagnosis of Parkinson's Disease Based on the PPMI Database From 2012 to 2018: A Retrospective Cross-Sectional Study.Health science reports · 2026Article
- A qPCR-based approach targeting the microbial gene markerJournal of Parkinson's disease · 2026Article
- Prevalence and Impact of Probable REM Sleep Behavior Disorder in Essential Tremor: A Multicenter Cross-Sectional Study.European journal of neurology · 2026Article
- Advances in autonomic dysfunction research in Parkinson's disease.Frontiers in aging neuroscience · 2025Review
- Rapid eye movement sleep behavior disorder is associated with decreased quality of life and stigma in people with Parkinson's disease.Acta neurologica Belgica · 2023Article
- Clinico-imaging features of subjects at risk of Lewy body disease in NaT-PROBE baseline analysis.NPJ Parkinson's disease · 2023Article
- Olfactory Impairment Is the Main Predictor of Higher Scores at REM Sleep Behavior Disorder (RBD) Screening Questionnaire in Parkinson's Disease Patients.Brain sciences · 2023Article
- Factors contributing to sleep disturbances and excessive daytime sleepiness in patients with Parkinson's disease.Frontiers in neurology · 2023Article
- Associations between non-motor symptoms and patient characteristics in Parkinson's disease: a multicenter cross-sectional study.Frontiers in aging neuroscience · 2023Article
- My History in Juntendo University.Juntendo Iji zasshi = Juntendo medical journal · 2023Article
- Neurologic and psychiatric features of impending neurodegeneration in iRBD.Clinical parkinsonism & related disorders · 2023Article
- Apathy in Parkinson's Disease: Defining the Park Apathy Subtype.Brain sciences · 2022Review
- Sleep and Autonomic Manifestations in Parkinson's Disease Complicated With Probable Rapid Eye Movement Sleep Behavior Disorder.Frontiers in neuroscience · 2022Article
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRapid eye movement sleep behavior disorder (RBD) and olfactory dysfunction are useful for early diagnosis of Parkinson's disease (PD). RBD and severe olfactory dysfunction are also regarded as risk factors for cognitive impairment in PD. This study aimed to assess the associations between RBD, olfactory function, and clinical symptoms in patients with PD.
methodsThe participants were 404 patients with non-demented PD. Probable RBD (pRBD) was determined using the Japanese version of the RBD screening questionnaire (RBDSQ-J) and the RBD Single-Question Screen (RBD1Q). Olfactory function was evaluated using the odor identification test for Japanese. Clinical symptoms were evaluated using the Movement Disorder Society Revision of the Unified PD Rating Scale (MDS-UPDRS) parts I-IV.
resultsIn total, 134 (33.2%) patients indicated a history of pRBD as determined by the RBD1Q and 136 (33.7%) by the RBDSQ-J based on a cutoff value of 6 points. Moreover, 101 patients were diagnosed as pRBD by both questionnaires, 35 by the RBDSQ-J only, and 33 by the RBD1Q only. The MDS-UPDRS parts I-III scores were significantly higher and disease duration significantly longer in the pRBD group. pRBD was significantly associated with male gender and the MDS-UPDRS part I score. The olfactory identification function was significantly reduced in the pRBD group.
conclusionsAbout 33% of the patients with PD had pRBD based on the questionnaires, and both motor and non-motor functions were significantly decreased in these patients. These results suggest that more extensive degeneration occurred in patients with non-demented PD with RBD.
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