ArticlePloS one2021
Genome-wide identification and expression profiling of glutathione S-transferase family under multiple abiotic and biotic stresses in Medicago truncatula L.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Integrative systems biology analysis of barley transcriptome ─ hormonal signaling against biotic stress.PloS one · 2023Pooled it
- Genome-Wide Identification of theGenes · 2026Article
- Comparative Leaf Proteome Analysis of Maize (Plants (Basel, Switzerland) · 2025Article
- Glutathione S-transferase in mediating adaptive responses of oats (Avena sativa) to osmotic and cadmium stress: genome-wide analysis.BMC plant biology · 2025Article
- Genome-wide identification, expression and functional analysis of glutathioneFrontiers in plant science · 2025Article
- Comprehensive analysis of the aldehyde dehydrogenase gene family inFrontiers in plant science · 2024Article
- Salinity stress tolerance prediction for biomass-related traits in maize (Zea mays L.) using genome-wide markers.The plant genome · 2023Article
- Genome-wide identification and characterization of glutathione3 Biotech · 2023Article
- Genome-wide in silico identification of glutathione S-transferase (GST) gene family members in fig (PeerJ · 2023Review
- Analysis of the mechanism of Ricinus communis L. tolerance to Cd metal based on proteomics and metabolomics.PloS one · 2023Article
- Genome-wide identification and characterization of glutathione S-transferase gene family in Musa acuminata L. AAA group and gaining an insight to their role in banana fruit development.Journal of applied genetics · 2022Article
- Computational insights into diverse aspects of glutathione S-transferase gene family in Papaver somniferum.Journal of plant research · 2022Article
- Exopolysaccharides from Lactobacillus plantarum reduces cadmium uptake and mitigates cadmium toxicity in rice seedlings.World journal of microbiology & biotechnology · 2022Article
- A calmodulin-like protein (CML10) interacts with cytosolic enzymes GSTU8 and FBA6 to regulate cold tolerance.Plant physiology · 2022Article
- Overexpression of a soybean Globin (GmGlb1-1) gene reduces plant susceptibility to Meloidogyne incognita.Planta · 2022Article
- Directed Evolution of Phi Class Glutathione Transferases Involved in Multiple-Herbicide Resistance of Grass Weeds and Crops.International journal of molecular sciences · 2022Article
- Aldehyde dehydrogenase superfamily in sorghum: genome-wide identification, evolution, and transcript profiling during development stages and stress conditions.BMC plant biology · 2022Article
- MtGSTF7, a TT19-like GST gene, is essential for accumulation of anthocyanins, but not proanthocyanins in Medicago truncatula.Journal of experimental botany · 2022Article
- Article
- Genome-wide identification and expression analysis of glutathione S-transferase gene family to reveal their role in cold stress response in cucumber.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione transferases (GSTs) constitute an ancient, ubiquitous, multi-functional antioxidant enzyme superfamily that has great importance on cellular detoxification against abiotic and biotic stresses as well as plant development and growth. The present study aimed to a comprehensive genome-wide identification and functional characterization of GST family in one of the economically important legume plants-Medicago truncatula. Here, we have identified a total of ninety-two putative MtGST genes that code for 120 proteins. All these members were classified into twelve classes based on their phylogenetic relationship and the presence of structural conserved domain/motif. Among them, 7 MtGST gene pairs were identified to have segmental duplication. Expression profiling of MtGST transcripts revealed their high level of organ/tissue-specific expression in most of the developmental stages and anatomical tissues. The transcripts of MtGSTU5, MtGSTU8, MtGSTU17, MtGSTU46, and MtGSTU47 showed significant up-regulation in response to various abiotic and biotic stresses. Moreover, transcripts of MtGSTU8, MtGSTU14, MtGSTU28, MtGSTU30, MtGSTU34, MtGSTU46 and MtGSTF8 were found to be highly upregulated in response to drought treatment for 24h and 48h. Among the highly stress-responsive MtGST members, MtGSTU17 showed strong affinity towards its conventional substrates reduced glutathione (GSH) and 1-chloro-2,4-dinitrobenzene (CDNB) with the lowest binding energy of-5.7 kcal/mol and -6.5 kcal/mol, respectively. Furthermore, the substrate-binding site residues of MtGSTU17 were found to be highly conserved. These findings will facilitate the further functional and evolutionary characterization of GST genes in Medicago.
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