ArticlePloS one2021
Larval nutrition influences adult fat stores and starvation resistance in Drosophila.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Moderate nutritional stress reprogrammes insulin responses to drive enhanced starvation tolerance in Drosophila melanogaster.The Journal of experimental biology · 2026Article
- Influence of developmental diet on adult energy reserves in Drosophila.BMC biology · 2025Article
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- Interaction between neuromuscular junction metabolic requirements in fragile X syndrome and glycogen storage disease models.Disease models & mechanisms · 2025Article
- Effects of Larval Starvation Stress on the Life History and Adult Fitness of Fall Webworm,Insects · 2025Article
- Nutritional stress in larvae induces adaptive responses that transcend generations in males of a model insect.The Journal of experimental biology · 2025Article
- Article
- A role for the circadian photoreceptor CRYPTOCHROME in regulating triglyceride metabolism in Drosophila.G3 (Bethesda, Md.) · 2024Article
- Correlated changes in stress resistance and biochemical parameters in response to long-term protein restriction inRoyal Society open science · 2024Article
- Safety Assessment of the Potential Probiotic Bacterium Limosilactobacillus fermentum J23 Using the Mexican Fruit Fly (Anastrepha ludens Loew, Diptera: Tephritidae) as a Novel In Vivo Model.Probiotics and antimicrobial proteins · 2024Article
- Energy Allocation of the Wolf SpiderInsects · 2023Article
- A protein restricted diet induces a stable increased fat storage phenotype in flies.Toxicology reports · 2023Article
- Genome-wide analysis identifies Homothorax and Extradenticle as regulators of insulin in Drosophila Insulin-Producing cells.PLoS genetics · 2022Article
- Drosophila Sirtuin 6 mediates developmental diet-dependent programming of adult physiology and survival.Aging cell · 2022Article
- Nutritional phenotype underlines the performance trade-offs ofCurrent research in insect science · 2022Article
- Nutrient dependentmicroPublication biology · 2022Article
- Characterization of Stress Responses in aBiomolecules · 2021Article
- Physiological and metabolomic consequences of reduced expression of the Drosophila brummer triglyceride Lipase.PloS one · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin plays a major role in connecting nutrient availability to energy homeostasis by regulating metabolic pathways. Defects in insulin signalling is the primary cause for diabetes, obesity and various metabolic disorders. Nutritional status during growth and developmental stages play a crucial role in determining adult size, fecundity and ageing. However, the association between developmental nutrition and adult metabolic disorders has not been fully explored. Here, we address the effects of nutrient status during the larval growth phase on adult metabolism in Drosophila. We report that restricted food supply in larvae led to higher fat reserves and starvation resistance in mature adult flies, which we attribute to low insulin signalling. A lesser amount of stored fat was mobilised during early adult stages and during acute starvation, which accounts for the metabolic effects. Furthermore, larval diet influenced the expression of fat mobilisation genes brummer and lipid storage droplet-2 in adult flies, which led to the metabolic phenotypes reported here. Thus, the restricted nutrient environment in developing larvae led to adaptive changes that entrain the adult flies for scarce food availability.
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