ArticlePloS one2021
Assessment of perinatal outcomes of pregnant women with severe versus simple malaria.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Meta-analysis of the prevalence of malaria associated with pregnancy in Colombia 2000-2020.PloS one · 2021Pooled it
- Modelling the Cost-Effectiveness of a Placental Malaria Vaccine in Sub-Saharan Africa.Vaccines · 2026Article
- A Rare Presentation ofCase reports in medicine · 2025Article
- Malaria Severity in the Elimination Continuum: A Retrospective Cohort Study between Beitbridge and Lupane Districts in Zimbabwe, 2021-2023.International journal of environmental research and public health · 2024Article
- Heterogeneity in the prevalence of subclinical malaria, other co-infections and anemia among pregnant women in rural areas of Myanmar: a community-based longitudinal study.Tropical medicine and health · 2024Article
- Availability of antimalarial medicines and inventory management at the community level: a case study of Bugesera district in Rwanda.BMC health services research · 2024Article
- Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study.BMC medicine · 2023Article
- Clinical and Parasitological Profiles of Gestational, Placental and Congenital Malaria in Northwestern Colombia.Tropical medicine and infectious disease · 2023Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMalaria in pregnancy is associated with adverse perinatal outcomes. The objective was to compare outcomes of simple and severe malaria and to determine whether they vary by trimester or severity of infection.
methodsProspective cohort study performed in 3 hospitals in Rwanda. Both hospitalized and non-hospitalized pregnant patients with confirmed malaria were enrolled and followed until 7 days postpartum. Demographic, clinical manifestations and perinatal outcomes were recorded.
resultsThere were 446 pregnant women with confirmed malaria and outcome data; 361 (80.9%) had simple malaria. Severe malaria was more common as pregnancy progressed; out of 85 with severe malaria, 12.9%, 29.4% and 57.6% were in the 1st, 2nd and 3rd trimesters (p<0.0001). Overall, a normal term delivery occurred in 57.6%, with preterm delivery in 24.9% and abortion in 13.5%. Adverse perinatal outcomes increased with trimester of infection (p<0.0001). Eight of the 9 early neonatal deaths had 3rd trimester infection (p<0.0001). There were 27 stillbirths; 63.7% were associated with 3rd trimester infection. A significant difference in perinatal outcomes between simple and severe malaria was seen: 64% of women with simple malaria had a normal term delivery as compared to 30.6% with severe malaria (p<0.0001). All complications were significantly greater with severe malaria.
conclusionOverall poor outcomes are seen in malaria with significant differences in perinatal outcomes between simple and severe malaria and by trimester of infection. In addition to vector control and exposure prevention, efforts need to be made in screening, treatment education and monitoring pregnancies affected by malaria.
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