ArticlePloS one2021
Effects of dietary phosphates from organic and inorganic sources on parameters of phosphorus homeostasis in healthy adult dogs.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Association Between Dietary Regimen and Renal Function Parameters in African Pygmy Hedgehogs (Animals : an open access journal from MDPI · 2026Article
- Advances in Functional Pet Food Research: Health-Driven Ingredients, Nutritional Targets and Evidence-Based Claims.Animals : an open access journal from MDPI · 2026Review
- Hypophosphatemia in Intensive Care Unit Canine Patients: Occurrence and Association With Mortality and Duration of Hospitalization.Veterinary clinical pathology · 2025Article
- Apparent digestibility and calcium and phosphorus in urine after feeding different combinations of calcium and phosphorus sources to adult dogs.Journal of animal physiology and animal nutrition · 2025Article
- Unraveling the Effects of Hexametaphosphate: Insights into Trypsin Aggregation and Structural Reversal.ACS omega · 2024Article
- Multispectroscopic and computational insights into amyloid fibril formation of alpha lactalbumin induced by sodium hexametaphosphate.Scientific reports · 2024Article
- A Meta-Analysis on Quantitative Calcium, Phosphorus and Magnesium Metabolism in Horses and Ponies.Animals : an open access journal from MDPI · 2024Review
- Organic phosphate but not inorganic phosphate regulatesiScience · 2024Article
- Article
- Speciation of Phosphorus in Pet Foods by Solid-StateJournal of agricultural and food chemistry · 2023Article
- Mineral and heavy metal content in dry dog foods with different main animal components.Scientific reports · 2023Article
- High Intake of Sodium Chloride for 28 Days Causes No Effect on Serum FGF23 Concentrations in Cats.Animals : an open access journal from MDPI · 2022Article
- The Source Matters-Effects of High Phosphate Intake from Eight Different Sources in Dogs.Animals : an open access journal from MDPI · 2021Article
- Dry Pet Food Flavor Enhancers and Their Impact on Palatability: A Review.Foods (Basel, Switzerland) · 2021Review
- No Observed Adverse Effects on Health Were Detected in Adult Beagle Dogs When Fed a High-Calcium Diet for 40 Weeks.Animals : an open access journal from MDPI · 2021Article
- Long-term safety of dietary salt: A 5-year ProspEctive rAndomized bliNded and controlled stUdy in healThy aged cats (PEANUT study).Journal of veterinary internal medicineArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of dietary phosphorus (P) excess, especially on renal and cardiovascular health, has been investigated in several species, but little is known in dogs.
objectiveThe aim of this study was to examine effects of different P sources on concentration and postprandial kinetics of selected parameters of P homeostasis in dogs.
methodsEight beagles received one control diet (P 0.5% dry matter [DM]) and three high P diets (poultry meal, NaH2PO4, and KH2PO4; P 1.7% DM) for 18d. Urine samples were collected pre- and postprandially while faeces were collected quantitatively for 5d and analysed for minerals. On day 18, blood was sampled 1h pre- and 0.5, 1, 1.5, 2, 3, 5 and 7h postprandially.
resultsPi (KH2PO4, NaH2PO4) but not organic P caused an increased apparent P digestibility and significantly influenced kinetics of serum FGF23, parathyroid hormone, P, CrossLaps and bonespecific alkaline phosphatase, demonstrating a disrupted calcium (Ca) and P homeostasis with potential harm for renal, cardiovascular and skeletal health.
conclusionsResults of feeding Pi to dogs indicate distinct disturbances of Ca and P metabolism, in contrast to organic sources. The use of Pi in food can therefore not be considered as safe. Further research, especially on dose and long-term effects, is warranted.
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