Evidence map›Paper›PMID 33606739›Full record

Trial reportPloS one2021

Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial.

Marcos Antonio Marton Filho, Rodrigo Leal Alves, Paulo do Nascimento, Gabriel Dos Santos Tarquinio, Paulo Ferreira Mega, Norma Sueli Pinheiro Módolo

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05612802 (A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05612802 nacompletednot on this mapstarted 2023, after this paper: background citation

A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)

TypeinterventionalSponsorBaskent UniversityRan2023 to 2023Enrolled25ConditionsAcute Kidney Injury (Nontraumatic), PneumoperitoneumArmsIGF-1
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Marcos Antonio Marton FilhoDepartment of Surgical Specialties and Anesthesiology, Botucatu School of Medicine, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil.ORCID 0000-0003-0234-1258
Rodrigo Leal AlvesDepartment of Anesthesiology, São Rafael Hospital and Federal University of Bahia, Salvador, Brazil.
Paulo do NascimentoDepartment of Surgical Specialties and Anesthesiology, Botucatu School of Medicine, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil.
Gabriel Dos Santos TarquinioClínica de Anestesiologia de Ribeirão Preto (CARP), Ribeirão Preto, São Paulo, Brazil.
Paulo Ferreira MegaSchool of Medicine, Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS), Campinas, São Paulo, Brazil.
Norma Sueli Pinheiro MódoloDepartment of Surgical Specialties and Anesthesiology, Botucatu School of Medicine, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil.
Universidade Estadual Paulista (Unesp) · BRPontifícia Universidade Católica de Campinas · BRSociedade Brasileira de Anestesiologia · BRUniversidade de Ribeirão Preto · BRUniversidade Federal da Bahia · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased intra-abdominal pressure causes hemodynamic changes that may affect renal biomarkers.

methodsThis randomized, single-blind, single-center clinical trial recruited patients undergoing laparoscopic cholecystectomy at a tertiary care center in Brazil. They were randomly allocated to a standard intra-abdominal pressure group (P10-12, 10-12 mm Hg) and a low intra-abdominal pressure group (P6-8, 6-8 mm Hg). The primary outcome was the change in neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C levels measured at the beginning of the procedure (T0), at the end of the procedure (T1), and 24 hours after the procedure (T2). P-values < 0.05 were considered statistically significant.

resultsIn total, 64 patients completed the study-33 were given standard pressure and 31 were given low pressure. There was no significant difference in the biomarker between the groups (P = 0.580), but there was a significant difference between the time points with elevation at T1 (P < 0.001). Similar to NGAL, cystatin C had an elevation at T1 in both groups (P = 0.021), but no difference was found when comparing the groups.

conclusionsIn laparoscopic cholecystectomy, pneumoperitoneum increases NGAL and cystatin C levels intraoperatively, and the use of low-pressure pneumoperitoneum does not change the course of these biomarkers.

Indexed as

AdultAgedBiomarkersCholecystectomy, LaparoscopicCystatin CFemaleHumansKidney DiseasesLipocalin-2MaleMiddle AgedPneumoperitoneumPostoperative PeriodSingle-Blind MethodTertiary Care CentersBiomarkersCystatin CLCN2 protein, humanLipocalin-2

Identifiers

PMID33606739
PMCPMC7895340
OpenAlexW3132199430

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.