Evidence map›Paper›PMID 33606659›Full record

ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2021

Prevalence and predictors of potentially inappropriate prescribing in middle-aged adults: a repeated cross-sectional study.

Amandeep Khatter, Frank Moriarty, Mark Ashworth, Stevo Durbaba, Patrick Redmond

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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  19. Appropriateness of the Prescription and Use of Medicines: An Old Concept but More Relevant than Ever.International journal of environmental research and public health · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Amandeep KhatterSchool of Population Health and Environmental Sciences, King's College London, London, UK.
Frank MoriartySchool of Pharmacy and Biomolecular Sciences.
Mark AshworthSchool of Population Health and Environmental Sciences, King's College London, London, UK.
Stevo DurbabaSchool of Population Health and Environmental Sciences, King's College London, London, UK.
Patrick RedmondDepartment of General Practice, Royal College of Surgeons in Ireland, Dublin, Ireland.
King's College London · GBRoyal College of Surgeons in Ireland · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPotentially inappropriate prescribing (PIP) is common in older adults and known to be associated with polypharmacy and multimorbidity. Less is known about the prevalence and causes of PIP in middle-aged adults.

aimTo determine the prevalence and predictors of PIP in middle-aged adults. DESIGN AND

settingA repeated cross-sectional study was conducted using primary care data in London.

methodPIP was defined using the PRescribing Optimally in Middle-aged People's Treatments (PROMPT) criteria. Prescribing and demographic data were extracted from Lambeth DataNet (LDN), a pseudonymised database of all patients registered at general practices in Lambeth, for those aged 45-64 years prescribed ≥1 medicines in each year from 2014-2019 (

resultsThe prevalence of PIP decreased from 20% in 2014 to 18% in 2019. The most prevalent PROMPT criteria in 2019 were the use of ≥2 drugs from the same pharmacological class (7.6%), use of non-steroidal anti-inflammatory drugs for >3 months (7.1%) and use of proton pump inhibitors above recommended maintenance dosages for >8 weeks (3.1%). Over the study period, the prevalence of multimorbidity increased (47-52%) and polypharmacy remained stable (27%). Polypharmacy, multimorbidity, deprivation, and age were independently associated with PIP. Sex was the only variable not associated with PIP.

conclusionAlmost one-fifth of middle-aged adults prescribed medicines are exposed to PIP, as defined by the PROMPT criteria. This is likely to be linked with exposure to avoidable adverse drug events. The PROMPT criteria may provide a useful aid in interventions to optimise prescribing.

Indexed as

Inappropriate PrescribingPolypharmacyAgedCross-Sectional StudiesHumansMiddle AgedMultimorbidityPrevalenceanti-inflammatory agentsdrug-related side effects and adverse reactionsgeneral practiceinappropriate prescribingmiddle agedmultimorbiditynon-steroidalpolypharmacy

Identifiers

PMID33606659
PMCPMC8136579
OpenAlexW3131253021

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.