Evidence map›Paper›PMID 33606602›Full record

ArticleAmerican journal of respiratory cell and molecular biology2021

Postexposure Liponucleotide Prophylaxis and Treatment Attenuates Acute Respiratory Distress Syndrome in Influenza-infected Mice.

Lucia E Rosas, Lauren M Doolittle, Lisa M Joseph, Hasan El-Musa, Michael V Novotny, Judy M Hickman-Davis, R Duncan Hite, Ian C Davis

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Improving Mitochondrial Function in Viral Infection: Targeting Cellular Metabolism.American journal of respiratory cell and molecular biology · 2022
    Article
  6. Pathogenesis of pneumonia and acute lung injury.Clinical science (London, England : 1979) · 2022
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lucia E RosasDepartment of Veterinary Biosciences and.
Lauren M DoolittleDepartment of Veterinary Biosciences and.
Lisa M JosephDepartment of Veterinary Biosciences and.
Hasan El-MusaDepartment of Veterinary Biosciences and.
Michael V NovotnyDepartment of Immunology and Inflammation, Cleveland Clinic, Cleveland, Ohio; and.
Judy M Hickman-DavisDepartment of Veterinary Preventive Medicine, The Ohio State University, Columbus, Ohio.
R Duncan HiteDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio.
Ian C DavisDepartment of Veterinary Biosciences and.
Cleveland Clinic · USThe Ohio State University · USUniversity of Cincinnati · US

Funding

Role of alterations in the ATII cell lipidome in influenza pathogenesisR01HL137090 · NHLBI · OHIO STATE UNIVERSITY · PI DAVIS, IAN CHRISTOPHER · 2017 to 2020
$2.5M
Short Trem Research Training for Veterinary StudentsT35OD010977 · OD · OHIO STATE UNIVERSITY · PI Christine A Petersen · 2012 to 2026
$1.1M
NHLBI NIH HHS R01 HL137090NIH HHS T35 OD010977
6 · The paper itself

Abstract

There is an urgent need for new drugs for patients with acute respiratory distress syndrome (ARDS), including those with coronavirus disease (COVID-19). ARDS in influenza-infected mice is associated with reduced concentrations of liponucleotides (essential precursors for

Indexed as

Alveolar Epithelial CellsAnimalsCOVID-19COVID-19 Drug TreatmentCytidine Diphosphate CholineCytidine Diphosphate DiglyceridesInfluenza A Virus, H1N1 SubtypeMiceOrthomyxoviridae InfectionsRespiratory Distress SyndromeSARS-CoV-2Cytidine Diphosphate CholineCytidine Diphosphate Diglyceridesalveolar type II cellinfluenzaliponucleotidephospholipidsurfactant

Identifiers

PMID33606602
PMCPMC8456882
OpenAlexW3131873568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.