Evidence map›Paper›PMID 33606587›Full record

ReviewAmerican journal of physiology. Heart and circulatory physiology2021

Apoptosis in resistance arteries induced by hydrogen peroxide: greater resilience of endothelium versus smooth muscle.

Rebecca L Shaw, Charles E Norton, Steven S Segal

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Differential Effects of High Fat Diets on Resilience to HAntioxidants (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Review
  9. Review
  10. Smad2 inhibition ofAtherosclerosis plus · 2021
    Article
  11. Reactive Oxygen Species and Endothelial CaInternational journal of molecular sciences · 2021
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rebecca L ShawDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.
Charles E NortonDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.
Steven S SegalDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.ORCID 0000-0001-5667-2154
University of Missouri · US

Funding

Intercellular Coordination of Blood Flow ControlR37HL041026 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SEGAL, STEVEN S · 2008 to 2018
$3.7M
HHS | National Institutes of Health (NIH) R37-HL041026NHLBI NIH HHS R37 HL041026
6 · The paper itself

Abstract

Reactive oxygen species (ROS) are implicated in cardiovascular and neurologic disorders including atherosclerosis, heart attack, stroke, and traumatic brain injury. Although oxidative stress can lead to apoptosis of vascular cells, such findings are largely based upon isolated vascular smooth muscle cells (SMCs) and endothelial cells (ECs) studied in culture. Studying intact resistance arteries, we have focused on understanding how SMCs and ECs in the blood vessel wall respond to acute oxidative stress induced by hydrogen peroxide, a ubiquitous, membrane-permeant ROS. We find that apoptosis induced by H

Indexed as

AnimalsApoptosisCalcium SignalingCell CommunicationEndoplasmic ReticulumEndothelial CellsEndothelium, VascularEnergy MetabolismFemaleHumansHydrogen PeroxideMaleMitochondriaMuscle, Smooth, VascularMyocytes, Smooth MuscleOxidative StressHydrogen PeroxideReactive Oxygen Speciesendothelial cellsendotheliumoxidative stressvascular smooth musclevascular smooth muscle cells

Identifiers

PMID33606587
PMCPMC8260393
OpenAlexW3132320039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.