Evidence map›Paper›PMID 33606344›Full record

ArticleCancer science2021

Radioimmunotherapy with an

Hiroki Takashima, Yoshikatsu Koga, Shino Manabe, Kazunobu Ohnuki, Ryo Tsumura, Takahiro Anzai, Nozomi Iwata, Yang Wang, Takuya Yokokita, Yukiko Komori and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Tumor Targeting ofMolecular pharmaceutics · 2023
    Article
  6. Diagnostics (Basel, Switzerland) · 2022
    Article
  7. Review
  8. Review
  9. Stabilization of anACS omega · 2021
    Article
  10. Radioimmunotherapy with anCancer science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Hiroki TakashimaDivision of Developmental Therapeutics, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.ORCID https://orcid.org/0000-0001-6487-7344
Yoshikatsu KogaDivision of Developmental Therapeutics, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.ORCID https://orcid.org/0000-0002-8404-585X
Shino ManabeLaboratory of Functional Molecule Chemistry, Pharmaceutical Department and Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan.ORCID https://orcid.org/0000-0002-2763-1414
Kazunobu OhnukiDivision of Functional Imaging, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Ryo TsumuraDivision of Developmental Therapeutics, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.ORCID https://orcid.org/0000-0003-1732-9171
Takahiro AnzaiDivision of Developmental Therapeutics, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Nozomi IwataDivision of Developmental Therapeutics, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Yang WangNishina Center for Accelerator-Based Science, RIKEN, Wako, Japan.
Takuya YokokitaNishina Center for Accelerator-Based Science, RIKEN, Wako, Japan.
Yukiko KomoriNishina Center for Accelerator-Based Science, RIKEN, Wako, Japan.
Daiki MoriNishina Center for Accelerator-Based Science, RIKEN, Wako, Japan.
Sachiko UsudaNishina Center for Accelerator-Based Science, RIKEN, Wako, Japan.
Hiromitsu HabaNishina Center for Accelerator-Based Science, RIKEN, Wako, Japan.
Hirofumi FujiiDivision of Functional Imaging, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Yasuhiro MatsumuraDepartment of Immune Medicine, National Cancer Center Research Institute, National Cancer Center, Chuo-ku, Tokyo, Japan.
Masahiro YasunagaDivision of Developmental Therapeutics, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.ORCID https://orcid.org/0000-0003-3356-0197
National Cancer Center Hospital East · JPRIKEN Nishina Center · JPNational Cancer Research Institute · GBTohoku University · JP

Funding

Japan Agency for Medical Research and Development (AMED) 19cm0106237h0002JSPS Grant-in-Aid for Scientific Research on Innovative Areas 16H06278National Cancer Center Research and Development Fund 2020-A-9National Cancer Center Research and Development Fund 29-A-9National Cancer Center Research and Development Fund 30-S-4RIKEN Engineering Network Project
6 · The paper itself

Abstract

Tissue factor (TF), the trigger protein of the extrinsic blood coagulation cascade, is abundantly expressed in various cancers including gastric cancer. Anti-TF monoclonal antibodies (mAbs) capable of targeting cancers have been successfully applied to armed antibodies such as antibody-drug conjugates (ADCs) and molecular imaging probes. We prepared an anti-TF mAb, clone 1084, labeled with astatine-211 (

Indexed as

AnimalsAntibodies, Monoclonal, HumanizedAscorbic AcidAstatineBlood CoagulationBody WeightCell Line, TumorErb-b2 Receptor Tyrosine KinasesFemaleHeterograftsHumansImmunoconjugatesLinear Energy TransferMiceMice, Inbred BALB CMice, NudeAntibodies, Monoclonal, HumanizedAscorbic AcidAstatineAstatine-211ERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesImmunoconjugatesRadiation-Protective AgentsThromboplastinantibody denaturationastatine-211radioimmunotherapysodium ascorbatetissue factor

Identifiers

PMID33606344
PMCPMC8088967
OpenAlexW3130070836

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.