ArticleHippocampus2021
Rodent mnemonic similarity task performance requires the prefrontal cortex.
Article in Hippocampus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- VTA-forebrain connectivity moderates adaptive behavior.Brain structure & function · 2026Review
- Hippocampal-prefrontal connectivity relates to inter-individual differences and training gains in distinguishing similar memories.Communications biology · 2025Article
- A compressed code for memory discrimination.bioRxiv : the preprint server for biology · 2025Article
- Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents.Neuroscience and biobehavioral reviews · 2025Review
- The effects of moderate prenatal alcohol exposure on performance in object and spatial discrimination tasks by adult male rats.Behavioural brain research · 2025Article
- Between similarity and difference: network dynamics of the hippocampal- parahippocampal circuitry in pattern separation of male Wistar rats.Frontiers in cellular neuroscience · 2025Article
- Demands on perceptual and mnemonic fidelity are a key determinant of age-related cognitive decline throughout the lifespan.Journal of experimental psychology. General · 2024Article
- Article
- Muscimol inactivation of dorsal striatum in young and aged male rats does not affect paired associates learning performance.Behavioral neuroscience · 2023Article
- Parsing memory and nonmemory contributions to age-related declines in mnemonic discrimination performance: a hierarchical Bayesian diffusion decision modeling approach.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Article
- Intrinsic functional connectivity in the default mode network predicts mnemonic discrimination: A connectome-based modeling approach.Hippocampus · 2022Article
- Entorhinal cortical Island cells regulate temporal association learning with long trace period.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Mnemonic similarity task performance, in which a known target stimulus must be distinguished from similar lures, is supported by the hippocampus and perirhinal cortex. Impairments on this task are known to manifest with advancing age. Interestingly, disrupting hippocampal activity leads to mnemonic discrimination impairments when lures are novel, but not when they are familiar. This observation suggests that other brain structures support discrimination abilities as stimuli are learned. The prefrontal cortex (PFC) is critical for retrieval of remote events and executive functions, such as working memory, and is also particularly vulnerable to dysfunction in aging. Importantly, the medial PFC is reciprocally connected to the perirhinal cortex and neuron firing in this region coordinates communication between lateral entorhinal and perirhinal cortices to presumably modulate hippocampal activity. This anatomical organization and function of the medial PFC suggests that it contributes to mnemonic discrimination; however, this notion has not been empirically tested. In the current study, rats were trained on a LEGO object-based mnemonic similarity task adapted for rodents, and surgically implanted with guide cannulae targeting prelimbic and infralimbic regions of the medial PFC. Prior to mnemonic discrimination tests, rats received PFC infusions of the GABA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.