Evidence map›Paper›PMID 33606323›Full record

ArticleHead & neck2021

Outcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy.

Kaveh Zakeri, Huili Wang, Jung Julie Kang, Anna Lee, Paul Romesser, Nader Mohamed, Daphna Gelblum, Eric Sherman, Lara Dunn, Jay Boyle and 7 more

Open access · greenAbstract read
In one paragraph

Article in Head & neck, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Contemporary Management of Malignancies of the Parotid Gland: A State-of-the-Art Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The evolving landscape of salivary gland tumors.CA: a cancer journal for clinicians
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Kaveh ZakeriDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.ORCID 0000-0003-3921-480X
Huili WangDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
Jung Julie KangDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
Anna LeeDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
Paul RomesserDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
Nader MohamedDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
Daphna GelblumDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
Eric ShermanDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
Lara DunnDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.ORCID 0000-0001-5318-2571
Jay BoyleDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
Richard WongDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
Linda ChenDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
Yao YuDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
C Jillian TsaiDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.ORCID 0000-0003-0400-2655
Sean M McBrideDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
Nadeem RiazDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
Nancy LeeDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York City, USA.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundProton beam radiation therapy (PBRT) has dosimetric advantages compared to photon radiation therapy for the treatment of major salivary gland tumors (MSGTs).

methodsPatients with non-metastatic MSGTs treated at a single proton therapy center from October 2013 to October 2018 were retrospectively reviewed.

resultsSixty-eight patients with MSGTs were included and the most common site and histology were the parotid gland (75.0%) and adenoid cystic carcinoma (22.1%), respectively. The 3-year rates of locoregional control, progression-free survival, and overall survival were 95.1% (95% CI: 89.9%-100.0%), 80.7% (70.2%-92.7%), and 96.1% (95% CI: 90.9%-100.0%), respectively.

conclusionIn a large cohort of MSGTs treated with PBRT, the rates of locoregional control were high in short-term follow-up and treatment was well tolerated.

Indexed as

Carcinoma, Adenoid CysticProton TherapySalivary Gland NeoplasmsHumansPrognosisRetrospective Studiescancerproton therapyradiationsalivary glandsurvival

Identifiers

PMID33606323
PMCPMC9371938
OpenAlexW3132520280

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.