Observational studyJournal of neuroscience research2021
Resilience, pain, and the brain: Relationships differ by sociodemographics.
Observational study in Journal of neuroscience research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- The effect of positive thinking on resilience and life satisfaction of older adults: a randomized controlled trial.Scientific reports · 2023Trial
- Associations Between Anthropometric Characteristics, Self-Reported Musculoskeletal and Visceral Symptoms, and Squat Movement Quality: A Cross-Section Study.Journal of functional morphology and kinesiology · 2026Article
- Musculoskeletal Pain Among Community-Dwelling Older Adults During the COVID-19 Pandemic: A Longitudinal Telesurvey.Physiotherapy Canada. Physiotherapie Canada · 2026Article
- A novel interpretable machine learning framework for predicting postpartum depression: a SHAP-based analysis of maternal and infant health indicators.Frontiers in psychiatry · 2026Article
- Dyadic Comparison of Pain and Stress in Alzheimer's Disease and Caregivers.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2025Article
- More than chronic pain: behavioural and psychosocial protective factors predict lower brain age in adults with/at risk of knee osteoarthritis over two years.Brain communications · 2025Article
- Chronic Pain Resilience Across Clinical Populations: A Concept Analysis.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2024Article
- Pain of Threatened Self: Explicit and Implicit Self-Esteem, Cortisol Responses to a Social Threat and Pain Perception.Journal of clinical medicine · 2024Article
- Environmental and sociocultural factors are associated with pain-related brain structure among diverse individuals with chronic musculoskeletal pain: intersectional considerations.Scientific reports · 2024Article
- Sex differences in the relationship between brain gray matter volume and psychological resilience in late adolescence.European child & adolescent psychiatry · 2024Article
- Broadening the Scope of Resilience in Chronic Pain: Methods, Social Context, and Development.Current rheumatology reports · 2024Review
- Estimation of cognitive impairment in chronic pain patients and characteristics of estimated mild cognitive impairment.Frontiers in neurology · 2024Article
- Elucidating individual differences in chronic pain and whole person health with allostatic load biomarkers.Brain, behavior, & immunity - health · 2023Article
- Cultural Framing and the Impact On Acute Pain and Pain Services.Current pain and headache reports · 2023Review
- Association between chronic pain and risk of incident dementia: findings from a prospective cohort.BMC medicine · 2023Article
- The Relationship Between Pain Intensity and Pain-Related Activity Patterns in Older Adults with Chronic Musculoskeletal Pain: Mediating Roles of Pain Resilience and Pain Catastrophizing.Journal of pain research · 2023Article
- Brain system segregation and pain catastrophizing in chronic pain progression.Frontiers in neuroscience · 2023Article
- Elucidating factors contributing to disparities in pain-related experiences among adults with or at risk for knee osteoarthritis.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- A scoping review on the methods of assessment and role of resilience on function and movement-evoked pain when experiencing a musculoskeletal injury.BMC musculoskeletal disorders · 2022Article
- Preferred Self-Administered Questionnaires to Assess Resilience, Optimism, Pain Acceptance, and Social Support in People with Pain: A Modified Delphi Study.Pain medicine (Malden, Mass.) · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Chronic musculoskeletal (MSK) pain is disabling to individuals and burdensome to society. A relationship between telomere length and resilience was reported in individuals with consideration for chronic pain intensity. While chronic pain associates with brain changes, little is known regarding the neurobiological interface of resilience. In a group of individuals with chronic MSK pain, we examined the relationships between a previously investigated resilience index, clinical pain and functioning measures, and pain-related brain structures, with consideration for sex and ethnicity/race. A cross-sectional analysis of 166 non-Hispanic Black and non-Hispanic White adults, 45-85 years of age with pain ≥ 1 body site (s) over the past 3 months was completed. Measures of clinical pain and functioning, biobehavioral and psychosocial resilience, and structural MRI were completed. Our findings indicate higher levels of resilience associate with lower levels of clinical pain and functional limitations. Significant associations between resilience, ethnicity/race, and/or sex, and pain-related brain gray matter structure were demonstrated in the right amygdaloid complex, bilateral thalamus, and postcentral gyrus. Our findings provide compelling evidence that in order to decipher the neurobiological code of chronic pain and related protective factors, it will be important to improve how chronic pain is phenotyped; to include an equal representation of females in studies including analyses stratifying by sex, and to consider other sociodemographic factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.