ArticleCancer2021
Do all patients with cancer experience fatigue? A longitudinal study of fatigue trajectories in women with breast cancer.
Article in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- Resilience in symptom response to cancer treatment: a new lens for examining variable symptom trajectories in older adults with advanced cancer.The oncologist · 2026Trial
- Effect of minocycline on changes in affective behaviors, cognitive function, and inflammation in breast cancer survivors undergoing chemotherapy: a pilot randomized controlled trial.Breast cancer research and treatment · 2024Trial
- Patient-Reported Outcomes in OlympiA: A Phase III, Randomized, Placebo-Controlled Trial of Adjuvant Olaparib in gJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Trial
- A systematic assessment of the short- and long-term effects of commonly used breast cancer chemotherapeutics on the gut microbiome‒blood‒brain axis of female mice.Gut microbes · 2026Article
- Long-Term Fatigue After Treatment for Breast Cancer.JAMA network open · 2026Article
- Observational
- Longitudinal Patterns of Symptoms in Patients Undergoing Chemotherapy: A Secondary Analysis of a Cluster Randomized Clinical Trial.JAMA network open · 2026Observational
- Cancer-related fatigue in cancer survivors: an updated clinical practice review for healthcare providers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
- Understanding, Recognizing, and Managing Cancer-Related Fatigue Associated with Breast Cancer.Current treatment options in oncology · 2026Review
- ATTITUDE - Addressing attrition in longitudinal cancer cohorts: an in-depth qualitative analysis of experiences and perspectives on participation in longitudinal studies among breast cancer survivors.Breast cancer research and treatment · 2026Observational
- A longitudinal analysis of symptom burden trajectories among breast cancer patients undergoing postoperative chemotherapy and related factors: a latent class growth model.Frontiers in public health · 2026Article
- Identifying core symptom clusters based on symptom distress levels in patients with maintenance hemodialysis: a cross-sectional network analysis.Renal failure · 2025Article
- The role of FGF21 in the metabolic adjustments required for exercise capacity.Life sciences · 2025Review
- Inflammation and dimensions of fatigue in women with early stage breast cancer: A longitudinal examination.Cancer · 2025Article
- Tracking cancer-related fatigue during chemotherapy: Insights from a comparative cohort study of early breast cancer patients.International journal of cancer · 2025Article
- Wellbeing status and priority concerns of patients with advanced renal cell carcinoma: results of the EONS PROMs project international online survey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Identification of distinct fatigue trajectories in patients with nasopharyngeal carcinoma undergoing radiotherapy: an observational longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Observational
- Network Analysis of Multidimensional Symptoms and Inflammatory Biomarkers in Chinese Patients with Glioma.Journal of inflammation research · 2025Article
- Current Status and Determinants of Fatigue in Chinese Older Adults Receiving Maintenance Hemodialysis: A Multicentre Cross-Sectional Study.Clinical interventions in aging · 2025Article
- Associations of three differential white blood cell counts, platelet counts, and their derived inflammatory indices with cancer-related fatigue in patients with breast cancer undergoing chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundFatigue is a common and expected side effect of cancer treatment. However, the majority of studies to date have focused on average levels of fatigue, which may obscure important individual differences in the severity and course of fatigue over time. The current study was designed to identify distinct trajectories of fatigue from diagnosis into survivorship in a longitudinal study of women with early-stage breast cancer.
methodsWomen with stage 0 to stage IIIA breast cancer (270 women) were recruited before (neo)adjuvant therapy with radiotherapy, chemotherapy, and/or endocrine therapy and completed assessments at baseline; posttreatment; and at 6 months, 12 months, and 18 months of follow-up. Growth mixture modeling was used to identify trajectories of fatigue, and differences among the trajectory groups with regard to demographic, medical, and psychosocial variables were examined.
resultsFive distinct trajectories of fatigue were identified: Stable Low (66%), with low levels of fatigue across assessments; Stable High (13%), with high fatigue across assessments; Decreasing (4%), with high fatigue at baseline that resolved over time; Increasing (9%), with low fatigue at baseline that increased over time; and Reactive (8%), with increased fatigue after treatment that resolved over time. Both psychological and treatment-related factors were found to be associated with fatigue trajectories, with psychological factors most strongly linked to high fatigue at the beginning of and over the course of treatment.
conclusionsThere is considerable variability in the experience of fatigue among women with early-stage breast cancer. Although the majority of women report relatively low fatigue, those with a history of depression and elevated psychological distress may be at risk of more severe and persistent fatigue.
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