Evidence map›Paper›PMID 33606210›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

Generating Ins2

Hamid R Shahshahan, Tyler N Kambis, Sumit Kar, Santosh K Yadav, Paras K Mishra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Genome Editing and Diabetic Cardiomyopathy.Advances in experimental medicine and biology · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hamid R ShahshahanDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA.
Tyler N KambisDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA.
Sumit KarDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA.
Santosh K YadavDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA.
Paras K MishraDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA. paraskumar.mishra@unmc.edu.
University of Nebraska Medical Center · US

Funding

Inflammation, miRNA and autophagy in diabetesR01HL113281 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MISHRA, PARAS KUMAR · 2013 to 2017
$1.9M
Exercise and H2S mitigate homocysteine-mediated beta2-adrenergic receptor dysfuncR01HL116205 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MISHRA, PARAS KUMAR · 2013 to 2017
$1.9M
NHLBI NIH HHS R01 HL113281NHLBI NIH HHS R01 HL116205
6 · The paper itself

Abstract

Diabetes mellitus (DM) is caused either due to insulin deficiency (T1DM) or insulin resistance (T2DM). DM increases the risk of heart failure by diabetic cardiomyopathy (DMCM), a cardiac muscle disorder that leads to a progressive decline in diastolic function, and ultimately systolic dysfunction. Mouse models of T1DM and T2DM exhibit clinical signs of DMCM. Growing evidence implicates microRNA (miRNA), an endogenous, non-coding, regulatory RNA, in the pathogenesis and signaling of DMCM. Therefore, inhibiting deleterious miRNAs and mimicking cardioprotective miRNAs could provide a potential therapeutic intervention for DMCM. miRNA-133a (miR-133a) is a highly abundant miRNA in the human heart. It is a cardioprotective miRNA, which is downregulated in the DM heart. It has anti-hypertrophic and anti-fibrotic effects. miR-133a mimic treatment after the onset of early DMCM can reverse histological and clinical signs of the disease in mice. We hypothesized that overexpression of cardiac-specific miR-133a in Ins2

Indexed as

AnimalsDiabetes Mellitus, ExperimentalDisease Models, AnimalDown-RegulationHeartHumansInsulinMiceMice, Inbred C57BLMicroRNAsMyocardiumMyocytes, CardiacIns2 protein, mouseInsulinMicroRNAsMirn133 microRNA, mouseAkitaCardiac physiologyDiabetes modelsTissue-specific transgenic mice

Identifiers

PMID33606210
PMCPMC9187299
OpenAlexW3129622662

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.