Evidence map›Paper›PMID 33606151›Full record

ArticleMolecular biology reports2021

Astragaloside IV inhibits palmitic acid-induced apoptosis through regulation of calcium homeostasis in mice podocytes.

Yingjun Zang, Shuang Liu, Aili Cao, Xiangyu Shan, Wenjuan Deng, Zhijun Li, Hao Wang, Yunman Wang, Li Wang, Wen Peng

Open access · hybridAbstract read
In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yingjun Zang *Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People's Republic of China.
Shuang Liu *Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People's Republic of China.
Aili CaoLaboratory of Renal Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 LanXi Road, Shanghai, 200062, People's Republic of China.
Xiangyu ShanDepartment of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People's Republic of China.
Wenjuan DengDepartment of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People's Republic of China.
Zhijun LiDepartment of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People's Republic of China.
Hao WangDepartment of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People's Republic of China.
Yunman WangDepartment of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People's Republic of China.
Li WangLaboratory of Renal Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 LanXi Road, Shanghai, 200062, People's Republic of China. wanglitcm2007@163.com.
Wen PengDepartment of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People's Republic of China. pengwen_01@vip.sina.com.
Shanghai University of Traditional Chinese Medicine · CN

Funding

Exploration Program of Putuo Hospital 2020360AKey Medical Discipline Project of Shanghai Municipal Health Bureau ZK2019A12National Natural Science Foundation of China 81403235, 81803921Planned Science Program of the Shanghai University of Traditional Chinese Medicine 2020LK070Science and Technology Innovation Project of Putuo District Health System PTKWWS202001Youth project of Shanghai Municipal Commission of Health and Family Planning 20154Y0133
6 · The paper itself

Abstract

Loss of podocytes is a hallmark of diabetic nephropathy, and a growing body of evidence indicates that podocytes are susceptible to palmitic acid (PA). We have previously shown that AS-IV inhibited PA-induced podocyte apoptosis by activating sarcoendoplasmic reticulum Ca

Indexed as

AnimalsApoptosisCalciumEndoplasmic ReticulumGene Expression RegulationHomeostasisImidazolesMembrane Potential, MitochondrialMiceMitochondriaPalmitic AcidPodocytesRNA, Small InterferingSaponinsTriterpenesTRPC6 Cation Channel1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazoleastragaloside ACalciumImidazolesPalmitic AcidRNA, Small InterferingSaponinsTriterpenesTRPC6 Cation ChannelAstragaloside IVCalcium homeostasisEndoplasmic reticulum stressPodocyte apoptosisTRPC6

Identifiers

PMID33606151
PMCPMC7925475
OpenAlexW3132070938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.