Evidence map›Paper›PMID 33606065›Full record

ArticleCancer immunology, immunotherapy : CII2021

Development and validation of a PD-L1/PD-1/CD8 axis-based classifier to predict cancer survival of upper tract urothelial carcinoma after radical nephroureterectomy.

Junyu Chen, Wenlong Zhong, Meng Yang, Weibin Hou, Xiaofei Wang, Kun Xia, Hao Yu, Meihua Yang, Bingkun Zhou, Bo Wang and 2 more

Abstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. SUSD2Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Junyu Chen *Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.
Wenlong Zhong *Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.
Meng Yang *Department of Urology, Yan' an Hospital of Kunming City, Kunming Medical University, Kunming, People's Republic of China.
Weibin HouDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.
Xiaofei WangDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.
Kun XiaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.
Hao YuDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.
Meihua YangDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.
Bingkun ZhouDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.
Bo WangDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China. wangb43@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-3307-6058
Jian HuangDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China. huangj8@mail.sysu.edu.cn.
Tianxin LinDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China. lintx@mail.sysu.edu.cn.

Funding

China Postdoctoral Science Foundation 2018M640862China Postdoctoral Science Foundation 2019M653196Fundamental Research Funds for the Central Universities 19ykpy116Fundamental Research Funds for the Central Universities 19ykpy117Guangdong Basic and Applied Basic Research Foundation 2020A1515011312National Natural Science Foundation of China 81772719National Natural Science Foundation of China 81825016National Natural Science Foundation of China 81902586National Natural Science Foundation of China 81961128027
6 · The paper itself

Abstract

The expression status of programmed cell death-ligand 1/programmed cell death 1 (PD-L1/PD-1) and the infiltration of CD8

Indexed as

Biomarkers, TumorAdultAgedAged, 80 and overB7-H1 AntigenCD8-Positive T-LymphocytesDisease SusceptibilityFemaleHumansImmunohistochemistryKaplan-Meier EstimateLymphocytes, Tumor-InfiltratingMaleMiddle AgedNeoplasm StagingNephroureterectomyB7-H1 AntigenBiomarkers, TumorCD274 protein, humanProgrammed Cell Death 1 ReceptorCD8Overall survivalPD-L1Prognostic classifierUpper tract urothelial carcinoma

Identifiers

PMID33606065
PMCPMC10992229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.