Evidence map›Paper›PMID 33605975›Full record

ArticleCardiovascular journal of Africa

The modulating effects of green rooibos (

Zimvo Obasa, Mignon Albertha van Vuuren, Barbara Huisamen, Shantal Lynn Windvogel

Open access · greenAbstract read
In one paragraph

Article in Cardiovascular journal of Africa. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zimvo ObasaCentre for Cardio-metabolic Research in Africa (CARMA), Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Email: maqeda@sun.ac.za.
Mignon Albertha van VuurenCentre for Cardio-metabolic Research in Africa (CARMA),Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Barbara HuisamenCentre for Cardio-metabolic Research in Africa (CARMA), Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, South Africa.
Shantal Lynn WindvogelCentre for Cardio-metabolic Research in Africa (CARMA), Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Stellenbosch University · ZA

Funding

Afriplex (Pty) LtdHarry Crossley FoundationSouth African Medical Research Council (SAMRC)
6 · The paper itself

Abstract

purposeObesity is associated with the development of risk factors for cardiovascular disease (CVD) and polyphenols have been shown to possess ameliorative effects against obesity-induced CVD risk factors. Rooibos (

methodsAdult male Wistar rats (

resultsHFD animals had (1) increased blood pressure, (2) impaired vasodilation, (3) attenuated PKB and AMPK expression, (4) decreased antioxidant enzyme activity, (5) increased malondialdehyde (MDA) levels, and (6) increased phosphorylated eNOS levels. Treatment with GRT extract significantly alleviated these obesity-induced CVD risk factors.

conclusionsSupplementation with GRT extract alleviated cardiovascular risk factors in the HFD animals, suggesting a therapeutic potential for GRT in obesity-induced cardiovascular risk.

Indexed as

AMP-Activated Protein KinasesAnimalsAntioxidantsAspalathusCardiovascular DiseasesMaleObesityPlant ExtractsPolyphenolsRatsRats, WistarAMP-Activated Protein KinasesAntioxidantsPlant ExtractsPolyphenolsAfriplex GRT™ extractblood pressureglucose homeostasisobesityoxidative stressvascular reactivity

Identifiers

PMID33605975
PMCPMC9219573
OpenAlexW3129843142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.