Observational studyJournal of pediatric gastroenterology and nutrition2021
Severe Acute Respiratory Syndrome Coronavirus-2 Infection in Children With Liver Transplant and Native Liver Disease: An International Observational Registry Study.
Observational study in Journal of pediatric gastroenterology and nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Impact of Respiratory Viral Infections in Transplant Recipients.Journal of the Pediatric Infectious Diseases Society · 2024Review
- Survey of pediatric transplant center practices regarding COVID-19 vaccine mandates for transplant candidates and living donors and use of COVID-19-positive deceased organs.Pediatric transplantation · 2023Article
- COVID-19-induced liver injury in infants, children, and adolescents.World journal of clinical pediatrics · 2023Review
- COVID-19 in pediatric lung transplant recipients: Clinical course and outcome.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Immunogenicity of an mRNA-Based COVID-19 Vaccine among Adolescents with Obesity or Liver Transplants.Vaccines · 2022Article
- AMMI Canada Practice Point on the treatment of acute COVID-19 in pediatrics.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2022Article
- SARS-CoV-2 Antibodies in Children with Chronic Disease from a Pediatric Gastroenterology Outpatient Clinic.Pediatric gastroenterology, hepatology & nutrition · 2022Article
- The impact of COVID-19 on the pediatric solid organ transplant population.Seminars in pediatric surgery · 2022Review
- Treatment adherence and behavior of pediatric liver transplant recipients during the COVID-19 pandemic.Pediatric transplantation · 2022Article
- Pediatric transplantation during the COVID-19 pandemic.World journal of transplantation · 2022Review
- Pediatric Acute Liver Failure Due to Type 2 Autoimmune Hepatitis Associated With SARS-CoV-2 Infection: A Case Report.JPGN reports · 2022Article
- Gastrointestinal, hepatic and pancreatic manifestations of COVID-19 in children.Clinics and research in hepatology and gastroenterology · 2022Review
- Return to School and COVID-19 Vaccination for Pediatric Solid Organ Transplant Recipients in the United States: Expert Opinion for 2021-2022.Journal of the Pediatric Infectious Diseases Society · 2022Article
- Which children and young people are at higher risk of severe disease and death after hospitalisation with SARS-CoV-2 infection in children and young people: A systematic review and individual patient meta-analysis.EClinicalMedicine · 2022Article
- Multisystem Inflammatory Syndrome Temporally Related to COVID-19 in Children From Latin America and the Caribbean Region: A Systematic Review With a Meta-Analysis of Data From Regional Surveillance Systems.Frontiers in pediatrics · 2022Review
- COVID-19 and Pediatric Gastroenterology.Pediatric clinics of North America · 2021Review
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Authors and funding
34 authors at 20 institutions in 6 countries.
Funding
Abstract
objectiveIncreased mortality risk because of severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) infection in adults with native liver disease (LD) and liver transplant (LT) is associated with advanced age and comorbid conditions. We aim to report outcomes for children with LD and LT enrolled in the NASPGHAN/SPLIT SARS-CoV2 registry.
methodsIn this multicenter observational cohort study, we collected data from 91 patients <21 years (LD 44, LT 47) with laboratory-confirmed SARS-CoV2 infection between April 21 and September 17, 2020.
resultsPatients with LD were more likely to require admission (70% vs 43% LT, P = 0.007) and pediatric intensive care unit (PICU) management (32% vs 4% LT, P = 0.001). Seven LD patients required mechanical ventilation (MV) and 2 patients died; no patients in the LT cohort died or required MV. Four LD patients presented in pediatric acute liver failure (PALF), 2 with concurrent multisystem inflammatory syndrome in children (MIS-C); all recovered without LT. Two LD patients had MIS-C alone and 1 patient died. Bivariable logistic-regression analysis found that patients with nonalcoholic fatty LD (NAFLD) (odds ratio [OR] 5.6, P = 0.02) and LD (OR 6.1, P = 0.01, vs LT) had higher odds of severe disease (PICU, vasopressor support, MV, renal replacement therapy or death).
conclusionsAlthough not directly comparable, LT recipients had lower odds of severe SARS-CoV2 infection (vs LD), despite immunosuppression burden. NAFLD patients reported to the registry had higher odds of severe SARS-CoV2 disease. Future controlled studies are needed to evaluate effective treatments and further stratify LD and LT patients with SARS-CoV2 infection.
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