ArticleBrain and behavior2021
Abnormal brain functional networks in end-stage renal disease patients with cognitive impairment.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Altered brain activity in patients with end-stage renal disease: A meta-analysis of resting-state functional imaging.Brain and behavior · 2023Pooled it
- Alterations of amplitude of low-frequency fluctuations and fractional amplitude of low-frequency fluctuations in end-stage renal disease on maintenance dialysis: An activation likelihood estimation meta-analysis.Frontiers in human neuroscience · 2022Pooled it
- Deteriorated Gray Matter Connectome in Diabetic Kidney Disease: A Graph Theory Analysis of Individual-Level Gray Matter Morphological Networks.Brain and behavior · 2025Article
- Neuroprotective Effects of Sodium Nitroprusside on CKD-Induced Cognitive Dysfunction in Rats: Role of CBS and Nrf2/HO-1 Pathway.Neuromolecular medicine · 2025Article
- Cortical structural network characteristics in non-cognitive impairment end-stage renal disease.Frontiers in neuroscience · 2024Article
- Multi-Modal Feature Selection with Feature Correlation and Feature Structure Fusion for MCI and AD Classification.Brain sciences · 2022Article
- Abnormal topological parameters in the default mode network in patients with impaired cognition undergoing maintenance hemodialysis.Frontiers in neurology · 2022Article
- Abnormal Dynamic Functional Connectivity in Patients With End-Stage Renal Disease.Frontiers in neuroscience · 2022Article
- Aberrant brain gray matter and functional networks topology in end stage renal disease patients undergoing maintenance hemodialysis with cognitive impairment.Frontiers in neuroscience · 2022Article
- Dynamic functional connectivity changes in the triple networks and its association with cognitive impairment in hemodialysis patients.Brain and behavior · 2021Article
- Abnormal brain functional networks in end-stage renal disease patients with cognitive impairment.Brain and behavior · 2021Article
- Associations of the Disrupted Functional Brain Network and Cognitive Function in End-Stage Renal Disease Patients on Maintenance Hemodialysis: A Graph Theory-Based Study of Resting-State Functional Magnetic Resonance Imaging.Frontiers in human neuroscience · 2021Article
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Authors and funding
5 authors.
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Abstract
introductionCognitive impairment (CI) is common in patients with end-stage renal disease (ESRD). Neuroimaging studies have demonstrated structural and functional brain alterations underlying CI in patients with ESRD. However, the patterns of change in whole-brain functional networks in ESRD patients with CI remain poorly understood.
methodsWe enrolled 66 patients with ESRD (36 patients with CI and 30 patients without CI) and 48 healthy control subjects (HCs). We calculated the topological properties using a graph theoretical analysis. An analysis of covariance (ANCOVA) was used to compare network metrics among the three groups. Moreover, we analyzed the relationships between altered network measures and clinical variables in ESRD patients with CI.
resultsCompared with HCs, both patient groups showed lower local efficiency and small-worldness. ESRD patients had decreased nodal centralities in the default mode regions and right amygdala. Comparison of the two patient groups showed significantly decreased global (small-worldness) and nodal (nodal centralities in the default mode regions) properties in the CI group. Altered nodal centralities in the bilateral medial part of the superior frontal gyrus, left posterior cingulate gyrus, and right precuneus were associated with cognitive performance in the CI group.
conclusionDisrupted brain functional networks were demonstrated in patients with ESRD, which were more severe in those with CI. Moreover, impaired nodal centralities in the default mode regions might underlie CI in patients with ESRD.
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