ArticleThe plant genome2021
A draft phased assembly of the diploid Cascade hop (Humulus lupulus) genome.
Article in The plant genome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- A Comprehensive Study of Hops (Plants (Basel, Switzerland) · 2026Review
- Extensive variation between chromosomes of North American and European hop.Nature communications · 2026Article
- Insights into glandular trichome biology from analysis of organ-specific gene expression programmes in cannabis, hop and tomato.The Plant journal : for cell and molecular biology · 2026Article
- Forensic Identification of Cannabis with Plant DNA Barcodes and Cannabinoid Synthesis Genes.Genes · 2025Article
- Abscisic Acid Enhances Ex Vitro Acclimatization Performance in Hop (International journal of molecular sciences · 2025Article
- Genome-wide DNA methylation analysis of CBCVd-infected hop plants (Microbiology spectrum · 2025Article
- Effects of Cytokinins on Morphogenesis, Total (Poly)Phenolic Content and Antioxidant Capacity of In Vitro-Cultured Hop Plantlets, cvs. Cascade and Columbus.Plants (Basel, Switzerland) · 2025Article
- Hop biomass waste against fire blight and black rot: an eco-friendly approach to crop protection.Frontiers in microbiology · 2025Article
- Chromosome-level Haploid Assembly of Cannabis sativa L. cv. Pink Pepper.Scientific data · 2024Article
- Unveiling the phenology and associated floral regulatory pathways of Humulus lupulus L. in subtropical conditions.Planta · 2024Article
- Exploring Pan-Genomes: An Overview of Resources and Tools for Unraveling Structure, Function, and Evolution of Crop Genes and Genomes.Biomolecules · 2023Review
- Recent Advances in Assembly of Complex Plant Genomes.Genomics, proteomics & bioinformatics · 2023Review
- The hops (Humulus lupulus) genome contains a mid-sized terpene synthase family that shows wide functional and allelic diversity.BMC plant biology · 2023Article
- An improved assembly of the "Cascade" hop (Horticulture research · 2023Article
- Era of gapless plant genomes: innovations in sequencing and mapping technologies revolutionize genomics and breeding.Current opinion in biotechnology · 2023Review
- Article
- In Vitro Propagation ofPlants (Basel, Switzerland) · 2022Article
- Two fingerprinting sets for Humulus lupulus based on KASP and microsatellite markers.PloS one · 2022Article
- Large structural variations in the haplotype-resolved African cassava genome.The Plant journal : for cell and molecular biology · 2021Article
- Developmental regulation of lupulin gland-associated genes in aromatic and bitter hops (Humulus lupulus L.).BMC plant biology · 2021Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hop (Humulus lupulus L. var Lupulus) is a diploid, dioecious plant with a history of cultivation spanning more than one thousand years. Hop cones are valued for their use in brewing and contain compounds of therapeutic interest including xanthohumol. Efforts to determine how biochemical pathways responsible for desirable traits are regulated have been challenged by the large (2.8 Gb), repetitive, and heterozygous genome of hop. We present a draft haplotype-phased assembly of the Cascade cultivar genome. Our draft assembly and annotation of the Cascade genome is the most extensive representation of the hop genome to date. PacBio long-read sequences from hop were assembled with FALCON and partially phased with FALCON-Unzip. Comparative analysis of haplotype sequences provides insight into selective pressures that have driven evolution in hop. We discovered genes with greater sequence divergence enriched for stress-response, growth, and flowering functions in the draft phased assembly. With improved resolution of long terminal retrotransposons (LTRs) due to long-read sequencing, we found that hop is over 70% repetitive. We identified a homolog of cannabidiolic acid synthase (CBDAS) that is expressed in multiple tissues. The approaches we developed to analyze the draft phased assembly serve to deepen our understanding of the genomic landscape of hop and may have broader applicability to the study of other large, complex genomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.