Evidence map›Paper›PMID 33604947›Full record

ArticleJournal of gastroenterology and hepatology2021

Dynamic changes in the pancreatitis activity scoring system during hospital course in a multicenter, prospective cohort.

Pedram Paragomi, Marie Tuft, Ioannis Pothoulakis, Vikesh K Singh, Tyler Stevens, Haq Nawaz, Jeffrey J Easler, Shyam Thakkar, Gregory A Cote, Peter J Lee and 13 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastroenterology and hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03075618 (Acute Pancreatitis Patient Registry To Examine Novel Therapies In Clinical Experiences), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03075618 completednot on this map

Acute Pancreatitis Patient Registry To Examine Novel Therapies In Clinical Experiences (APPRENTICE)

TypeobservationalSponsorUniversity of PittsburghRan2015 to 2020Enrolled623ConditionsPancreatitisArmsQuestionnaires
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Modified Pancreatitis Activity Scoring System Shows Distinct Trajectories in Acute Pancreatitis: An International Study.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Pedram ParagomiDepartment of Medicine, Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-5471-4979
Marie TuftDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ioannis PothoulakisMedStar Washington Hospital Center, Washington, District of Columbia, USA.
Vikesh K SinghDivision of Gastroenterology, John Hopkins Medical Institution, Baltimore, Maryland, USA.
Tyler StevensCleveland Clinic Foundation, Cleveland, Ohio, USA.
Haq NawazEastern Maine Medical Center, Bangor, Maine, USA.
Jeffrey J EaslerDivision of Gastroenterology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Shyam ThakkarDivision of Gastroenterology, West Virginia University, Morgantown, West Virginia, USA.
Gregory A CoteDivision of Gastroenterology, Medical University of South Carolina, Charleston, West Virginia, USA.
Peter J LeeDivision of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Venkata AkshintalaDivision of Gastroenterology, John Hopkins Medical Institution, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-8909-1951
Ayesha KamalDivision of Gastroenterology, John Hopkins Medical Institution, Baltimore, Maryland, USA.
Amir GougolDivision of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Anna Evans PhillipsDivision of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Jorge D MachicadoDivision of Gastroenterology, Mayo Clinic Healthcare System, Eau Claire, Wisconsin, USA.
David C WhitcombDivision of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Phil J GreerDivision of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
James L BuxbaumDivision of Gastroenterology, Department of Internal Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Phil HartDivision of Gastroenterology, Hepatology, and Nutrition, Ohio State University, Wexner Medical Center, Columbus, Ohio, USA.
Darwin ConwellDivision of Gastroenterology, Hepatology, and Nutrition, Ohio State University, Wexner Medical Center, Columbus, Ohio, USA.
Gong TangDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bechien U WuDivision of Gastroenterology, Kaiser Permanente, Pasadena, California, USA.
Georgios I PapachristouDivision of Gastroenterology, Hepatology, and Nutrition, Ohio State University, Wexner Medical Center, Columbus, Ohio, USA.

Funding

Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8M
Indiana University (IU) Clinical Center for Chronic Pancreatitis Clinical Research NetworkU01DK108323 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Jeffrey James Easler, Evan L Fogel · 2015 to 2026
$6.5M
NIDDK NIH HHS U01 DK108323
6 · The paper itself

Abstract

BACKGROUND AND

aimThe primary aim was to validate the Pancreatitis Activity Scoring System (PASS) in a multicenter prospectively ascertained acute pancreatitis (AP) cohort. Second, we investigated the association of early PASS trajectories with disease severity and length of hospital stay (LOS).

methodsData were prospectively collected through the APPRENTICE consortium (2015-2018). AP severity was categorized based on revised Atlanta classification. Delta PASS (ΔPASS) was calculated by subtracting activity score from baseline value. PASS trajectories were compared between severity subsets. Subsequently, the cohort was subdivided into three LOS subgroups as short (S-LOS): 2-3 days; intermediate (I-LOS): 3-7 days; and long (L-LOS): ≥7 days. The generalized estimating equations model was implemented to compare PASS trajectories.

resultsThere were 434 subjects analyzed including 322 (74%) mild, 86 (20%) moderately severe, and 26 (6%) severe AP. Severe AP subjects had the highest activity levels and the slowest rate of decline in activity (P = 0.039). Focusing on mild AP, L-LOS subjects (34%) had 28 points per day slower decline; whereas, S-LOS group (13%) showed 34 points per day sharper decrease compared with I-LOS (53%; P < 0.001). We noticed an outlier subset with a median admission-PASS of 466 compared with 140 in the rest. Morphine equivalent dose constituted 80% of the total PASS in the outliers (median morphine equivalent dose score = 392), compared with only 25% in normal-range subjects (score = 33, P value < 0.001).

conclusionsThis study highlighted that PASS can quantify AP activity. Significant differences in PASS trajectories were found both in revised Atlanta classification severity and LOS groups, which can be harnessed in AP monitoring/management (ClincialTrials.gov number, NCT03075618).

Indexed as

PancreatitisSeverity of Illness IndexAcute DiseaseHospitalizationHumansMorphine DerivativesProspective StudiesMorphine DerivativesAcute pancreatitisDisease activityLength of hospital stayPancreas

Identifiers

PMID33604947
PMCPMC9058811

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.