ArticleBreast cancer research and treatment2021
Analysis of the tumor characteristics in young age breast cancer patients using collaborative stage data of the Korea Central Cancer Registry.
Article in Breast cancer research and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Pathological characteristics and prognosis of very young patients with early breast cancer: a comparative analysis with older patients.Acta oncologica (Stockholm, Sweden) · 2026Article
- Risk factors for second primary cancer in patients who survive breast cancer.NPJ breast cancer · 2026Article
- Enhancing TNM Stage Completeness Using the SEER Summary Stage: A Nationwide Study From Korea.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- Machine learning-based prediction of disease-free survival in breast cancer patients with non-pathological complete response after neoadjuvant chemotherapy: a retrospective multicenter cohort study.American journal of cancer research · 2025Article
- Breast Cancer Statistics in Korea, 2021.Journal of breast cancer · 2024Review
- Proteogenomic analysis dissects early-onset breast cancer patients with prognostic relevance.Experimental & molecular medicine · 2024Article
- Custom target-sequencing in triple-negative and luminal breast cancer from young Brazilian patients.Clinics (Sao Paulo, Brazil) · 2024Article
- Development and validation of a random survival forest model for predicting long-term survival of early-stage young breast cancer patients based on the SEER database and an external validation cohort.American journal of cancer research · 2024Article
- Age-Related Incidence and Peak Occurrence of Contralateral Breast Cancer.JAMA network open · 2023Article
- Survival After Development of Contralateral Breast Cancer in Korean Patients With Breast Cancer.JAMA network open · 2023Article
- Osteoporosis Associated with Breast Cancer Treatments Based on Types of Hormonal Therapy: A Cross-Sectional Study Using Korean National Sample Data.Medicina (Kaunas, Lithuania) · 2023Article
- Prediction of breast cancer using blood microbiome and identification of foods for breast cancer prevention.Scientific reports · 2023Article
- Prognosis of pregnancy after breast cancer diagnosis according to the type of treatment: A population-based study in Korea by the SMARTSHIP group.Breast (Edinburgh, Scotland) · 2022Article
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12 authors.
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Abstract
purposeThis study aimed to evaluate tumor characteristics in young age (20-39 years old) breast cancer (YABC) patients in Korea. MATERIALS AND
methodsWe identified 10,897 breast cancer patients from 2010 to 2015. The data were collected through 10% systematic sampling of the Korea National Cancer Incidence Database (KNCI DB). Tumor size, lymph node status, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status were collected according to the Collaborative Stage version 2 (CSv2) Data Collection System.
resultsOf the 10,897 patients, 1245 (11.4%) were YABC patients. They were found to have larger tumors (T2: 41.6% in 20-39 age group vs 36.4% in 40-49 age group vs 36.5% in 50-59 age group vs 38.4% in ≥ 60 age group; T3: 10.1% vs 7.3% vs 6.5% vs 6.2%, P < .0001), greater rates of lymph node involvement (41.2% vs 32.7% vs 35.7% vs 32.5%, P < .0001), higher tumor grade (High grade: 26.8% vs 19.4% vs 23.5% vs 22.1%, P < .0001), and a larger proportion of triple-negative subtype (18.2% vs 11.0% vs 12.2% vs 13.5%, P < .0001). Compared to the 40-49 age group, breast cancer-related survival (BCRS) rates were worse (91.74% vs 95.04%, P < .0001), and the characteristics of YABC patients were associated with higher risk of death from breast cancer.
conclusionYABC patients have more aggressive tumor characteristics and worse survival rates. Therefore, we need to identify high-risk groups among YABC patients and support active surveillance in them. These findings from a national cohort provide important information for establishing a national cancer care strategy to manage YABC patients.
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