ArticlePlant physiology2021
Hexose transporter CsSWEET7a in cucumber mediates phloem unloading in companion cells for fruit development.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 69 citations in OpenAlex.
- The Microtubule-Associated Protein CsTON2 Interacts With CsTRM5 and CsSUN to Regulate Fruit Shape Development in Cucumber.Plant biotechnology journal · 2026Article
- Supplemental nitrogen induces robust physiological and molecular adaptations by enhancing carbon metabolism in maize.Protoplasma · 2026Article
- The DREB2C.L-IAGLU module contributes to long-term heat stress via sugar metabolism in cucumber.Horticulture research · 2026Article
- Transcriptional Regulation of SWEET15_A01 by MYB44/bHLH3 Modulates Carbon Allocation in Cotton Ovule and Fibre to Affect Seed and Fibre Traits.Plant biotechnology journal · 2026Article
- Molecular mechanisms and evolutionary adaptations of transporters for photosynthates and specialized metabolites in plants.Plant cell reports · 2026Review
- Comprehensive Identification and Expression Analysis of thePlants (Basel, Switzerland) · 2025Article
- Article
- Silencing of the Alkaline α-Galactosidase GeneInternational journal of molecular sciences · 2025Article
- Identification and Expression Pattern Analysis ofInternational journal of molecular sciences · 2025Article
- Tonoplast sugar transporters coordinately regulate tomato fruit development and quality.Plant communications · 2025Article
- Raffinose family oligosaccharide hydrolysis by alkaline α-galactosidase CsAGA2 controls seed development in cucumber.The Plant cell · 2025Article
- The transcription factors ERF105 and NAC72 regulate expression of a sugar transporter gene and hexose accumulation in grape.The Plant cell · 2024Article
- Characterization and Expression Analysis of Sugar Transporters through Partial Least Square Structural Equation Model (PLS-SEM) Revealed Their Role in Pepper (Plants (Basel, Switzerland) · 2024Article
- Sugar import mediated by sugar transporters and cell wall invertases for seed development inHorticulture research · 2024Article
- Sugar delivery at the tomato root and root galls after Meloidogyne incognita infestation.BMC plant biology · 2024Article
- Multi-Omics Analysis Reveals the Distinct Features of Metabolism Pathways Supporting the Fruit Size and Color Variation of Giant Pumpkin.International journal of molecular sciences · 2024Article
- Significance of Raffinose Family Oligosaccharides (RFOs) metabolism in plants.Advanced biotechnology · 2024Review
- Genome-Wide Identification and Expression Profile Analysis of Sugars Will Eventually Be Exported Transporter (International journal of molecular sciences · 2024Article
- Functional Characterization ofInternational journal of molecular sciences · 2024Article
- The Sink-Source Relationship in Cucumber (Plants (Basel, Switzerland) · 2023Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the fleshy fruit of cucumbers (Cucumis sativus L.), the phloem flow is unloaded via an apoplasmic pathway, which requires protein carriers to export sugars derived from stachyose and raffinose into the apoplasm. However, transporter(s) involved in this process remain unidentified. Here, we report that a hexose transporter, CsSWEET7a (Sugar Will Eventually be Exported Transporter 7a), was highly expressed in cucumber sink tissues and localized to the plasma membrane in companion cells of the phloem. Its expression level increased gradually during fruit development. Down-regulation of CsSWEET7a by RNA interference (RNAi) resulted in smaller fruit size along with reduced soluble sugar levels and reduced allocation of 14C-labelled carbon to sink tissues. CsSWEET7a overexpression lines showed an opposite phenotype. Interestingly, genes encoding alkaline α-galactosidase (AGA) and sucrose synthase (SUS) were also differentially regulated in CsSWEET7a transgenic lines. Immunohistochemical analysis demonstrated that CsAGA2 co-localized with CsSWEET7a in companion cells, indicating cooperation between AGA and CsSWEET7a in fruit phloem unloading. Our findings indicated that CsSWEET7a is involved in sugar phloem unloading in cucumber fruit by removing hexoses from companion cells to the apoplasmic space to stimulate the raffinose family of oligosaccharides (RFOs) metabolism so that additional sugars can be unloaded to promote fruit growth. This study also provides a possible avenue towards improving fruit production in cucumber.
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