Evidence map›Paper›PMID 33604575›Full record

ArticleFunction (Oxford, England)2021

Ethanol Disrupts Hormone-Induced Calcium Signaling in Liver.

Lawrence D Gaspers, Andrew P Thomas, Jan B Hoek, Paula J Bartlett

Open access · goldAbstract read
In one paragraph

Article in Function (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lawrence D GaspersDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.ORCID 0000-0002-5620-3283
Andrew P ThomasDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Jan B HoekDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Paula J BartlettDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Rutgers, The State University of New Jersey · USThomas Jefferson University · US

Funding

Ethanol Effects on the Transcriptional Regulatory Network in Liver Regeneration -R01AA018873 · NIAAA · THOMAS JEFFERSON UNIVERSITY · PI SRIVASTAVA, ANKITA · 2009 to 2025
$8.7M
Malaria melatonin receptor signaling as a novel drug targetR01AI099277 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI THOMAS, ANDREW P · 2012 to 2016
$2.1M
The role of hormone-evoked mitochondrial calcium increases in the pathogenesis ofR01AA017752 · NIAAA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI GASPERS, LAWRENCE D · 2008 to 2012
$1.7M
A novel ryanodine receptor in the hormonal regulation of hepatic metabolismR21DK082954 · NIDDK · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI THOMAS, ANDREW P · 2010 to 2011
$427k
NIAAA NIH HHS R01 AA017752NIAAA NIH HHS R01 AA018873NIAID NIH HHS R01 AI099277NIDDK NIH HHS R21 DK082954
6 · The paper itself

Abstract

Receptor-coupled phospholipase C (PLC) is an important target for the actions of ethanol. In the ex vivo perfused rat liver, concentrations of ethanol >100 mM were required to induce a rise in cytosolic calcium (Ca

Indexed as

Calcium SignalingInositol 1,4,5-TrisphosphateAnimalsEthanolHormonesInositol 1,4,5-Trisphosphate ReceptorsLiverRatsEthanolHormonesInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate Receptorscalcium signalingethanolgap junctionsinositol 1,4,5-trisphosphatereceptor-coupled phospholipase c

Identifiers

PMID33604575
PMCPMC7875097
OpenAlexW3119450004

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.