Evidence map›Paper›PMID 33604573›Full record

ReviewNeuro-oncology advances

New developments in neurofibromatosis type 2 and vestibular schwannoma.

Yin Ren, Divya A Chari, Sasa Vasilijic, D Bradley Welling, Konstantina M Stankovic

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05521048 (Doxycycline Injection of Cutaneous Schwannoma in Neurofibromatosis Type 2), which is not on this map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05521048 phase1 / phase2active not recruitingnot on this map

Doxycycline Injection of Cutaneous Schwannoma in Neurofibromatosis Type 2

TypeinterventionalSponsorMassachusetts Eye and Ear InfirmaryRan2022 to 2026Enrolled19ConditionsNeurofibromatosis Type 2ArmsDoxycycline Injection [Doxy]
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 63 citations in OpenAlex.

  1. Frailty, Surgical Time, and Surgical Complications Increase Length of Stay Following Large Vestibular Schwannoma Resection.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Angiotensin-Receptor Blockers Prevent Vestibular Schwannoma-Associated Hearing Loss.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
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  19. Article
  20. Natural history of hearing and tumor growth in vestibular schwannoma in neurofibromatosis type 2-related schwannomatosis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yin RenDepartment of Surgery, Division of Otolaryngology - Head and Neck Surgery, University of California San Diego School of Medicine, San Diego, California, USA.ORCID 0000-0002-3865-0012
Divya A ChariDepartment of Otolaryngology Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts, USA.
Sasa VasilijicDepartment of Otolaryngology Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts, USA.
D Bradley WellingDepartment of Otolaryngology Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9963-469X
Konstantina M StankovicDepartment of Otolaryngology Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-0233-279X
Massachusetts Eye and Ear Infirmary · USUniversity of California San Diego · US

Funding

Mechanisms of sensorineural hearing loss: secreted factorsR01DC015824 · NIDCD · STANFORD UNIVERSITY · PI STANKOVIC, KONSTANTINA M · 2016 to 2020
$2.2M
NIDCD NIH HHS R01 DC015824
6 · The paper itself

Abstract

Neurofibromatosis type 2 (NF2) is a rare autosomal dominant disorder characterized by the development of multiple nervous system tumors due to mutation in the

Indexed as

acoustic neuromaclinical trialsdrug repositioninghearing lossneurofibromatosis type 2NF2vestibular schwannoma

Identifiers

PMID33604573
PMCPMC7881257
OpenAlexW3098493169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.